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A novel sensing scheme is exemplified through the detection of ricin B-chain (RBC) in water and liquid food matrices: surface-enhanced Raman spectroscopy (SERS) coupled with an N-acetyl-galactosamine glycopolymer capture layer. The sensing scheme's detection limit was well below that of the predicted oral exposure limit. Theoretical predictions of the normal Raman spectrum of the glycomonomer give insight into polymer-RBC intermolecular interactions.
Bibliographical noteFunding Information:
This work was partially supported by the National Science Foundation through the University of Minnesota Materials Science Research and Engineering Center (DMR-1420013). Parts of this work were carried out in the College of Science & Engineering Characterization Facility University of Minnesota, which receives partial support from NSF through the MRSEC program. The SEM images were taken in the University of Minnesota I.T. Characterization Facility, which receives partial support from NSF through the NNIN program. L.R.M. and G.C.S. acknowledge supported from the NSF GRFP under Grant DGE-1324585 and by the MRSEC program at Northwestern University under Award DMR-1121262. We thank Zhe Gao for her assistance with the SEM images.
© 2016 American Chemical Society.
- DFT modeling
- film over nanospheres
- surface-enhanced raman spectroscopy
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