TY - JOUR
T1 - Serotype distribution of invasive group B streptococcal isolates in Maryland
T2 - Implications for vaccine formulation
AU - Harrison, Lee H.
AU - Elliott, John A.
AU - Dwyer, Diane M.
AU - Libonati, Joseph P.
AU - Ferrieri, Patricia
AU - Billmann, Lillian
AU - Schuchat, Anne
N1 - Funding Information:
Financial support: Centers for Disease Control and Prevention, National Vaccine Program, and Johns Hopkins University School of Hygiene and Public Health Faculty Development Fund.
PY - 1998
Y1 - 1998
N2 - Invasive group B streptococcal (GBS) infection is a major health problem among infants and adults. The formulation of GBS vaccines depends on knowledge of the GBS serotype distribution. Serotype V GBS infection appears to have recently emerged, suggesting that the serotype distribution changes over time. GBS isolates from 210 pediatric patients, 23 pregnant women, and 314 nonpregnant adults with invasive infection in Maryland were studied. The predominant serotypes from infants with early-onset disease were as follows: serotype III, 38% of isolates; serotype Ia, 36%; serotype V, 13%; and serotype II, 11%. Although the majority (60%) of isolates among infants with late-onset infection were serotype III, serotype Ia (23%) was also common. The predominant serotype among isolates from nonpregnant adult patients was serotype V, accounting for 29% of the isolates. The serotype distribution differs between pediatric patients and adults and is changing over time. The inclusion of a relatively small number of serotypes in a GBS vaccine could provide protection against the vast majority of isolates.
AB - Invasive group B streptococcal (GBS) infection is a major health problem among infants and adults. The formulation of GBS vaccines depends on knowledge of the GBS serotype distribution. Serotype V GBS infection appears to have recently emerged, suggesting that the serotype distribution changes over time. GBS isolates from 210 pediatric patients, 23 pregnant women, and 314 nonpregnant adults with invasive infection in Maryland were studied. The predominant serotypes from infants with early-onset disease were as follows: serotype III, 38% of isolates; serotype Ia, 36%; serotype V, 13%; and serotype II, 11%. Although the majority (60%) of isolates among infants with late-onset infection were serotype III, serotype Ia (23%) was also common. The predominant serotype among isolates from nonpregnant adult patients was serotype V, accounting for 29% of the isolates. The serotype distribution differs between pediatric patients and adults and is changing over time. The inclusion of a relatively small number of serotypes in a GBS vaccine could provide protection against the vast majority of isolates.
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U2 - 10.1086/515260
DO - 10.1086/515260
M3 - Article
C2 - 9534974
AN - SCOPUS:0031969228
SN - 0022-1899
VL - 177
SP - 998
EP - 1002
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -