SERCA Overexpression Improves Mitochondrial Quality Control and Attenuates Cardiac Microvascular Ischemia-Reperfusion Injury

Ying Tan, David Mui, Sam Toan, Pingjun Zhu, Ruibing Li, Hao Zhou

Research output: Contribution to journalArticlepeer-review

Abstract

This study indicates that sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) overexpression may be an effective approach to targeting cardiac microvascular ischemia/reperfusion injury by regulating calcium/XO/ROS signaling and preserving mitochondrial quality control.

Original languageEnglish (US)
Pages (from-to)696-707
Number of pages12
JournalMolecular Therapy - Nucleic Acids
Volume22
DOIs
StatePublished - Dec 4 2020
Externally publishedYes

Keywords

  • cardiac microvascular I/R injury
  • mitochondrial quality control
  • ROS
  • SERCA
  • XO

Fingerprint Dive into the research topics of 'SERCA Overexpression Improves Mitochondrial Quality Control and Attenuates Cardiac Microvascular Ischemia-Reperfusion Injury'. Together they form a unique fingerprint.

Cite this