We previously reported that paternally inherited human leukocyte antigen (HLA) alleles are a template for women's preferences for male odors (p = 0.0007). However, it has been suggested that sequence variation in a nearby olfactory receptor (OR) cluster on chromosome 6p influences smell preference. To determine whether the HLA-linked OR genes contribute to previously observed HLA-mediated behaviors, we use the odor preference data from our earlier study in combination with a new resequencing study of four functional, HLA-linked OR genes in the same subjects. Our results indicate that OR alleles in the genes surveyed are not in linkage disequilibrium with HLA variation and do not explain the previous findings of HLA-associated odor preference.
Bibliographical noteFunding Information:
The authors thank Yoav Gilad for primer design and helpful discussions regarding the manuscript. This work was supported by grants from the National Institutes of Health ( HD21244 , to C.O.) and T32 HL007605 (to E.E.T.) and by a Dennis W. Jahnigen/American Geriatrics Society fellowship (to J.M.P.).
- HLA alleles
- Linkage disequilibrium
- Olfactory receptor genes
- Smell preferences