Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors

Emma E. Thompson, Gabe Haller, Jayant M. Pinto, Ying Sun, Bethanne Zelano, Suma Jacob, Martha K. McClintock, Dan L. Nicolae, Carole Ober

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We previously reported that paternally inherited human leukocyte antigen (HLA) alleles are a template for women's preferences for male odors (p = 0.0007). However, it has been suggested that sequence variation in a nearby olfactory receptor (OR) cluster on chromosome 6p influences smell preference. To determine whether the HLA-linked OR genes contribute to previously observed HLA-mediated behaviors, we use the odor preference data from our earlier study in combination with a new resequencing study of four functional, HLA-linked OR genes in the same subjects. Our results indicate that OR alleles in the genes surveyed are not in linkage disequilibrium with HLA variation and do not explain the previous findings of HLA-associated odor preference.

Original languageEnglish (US)
Pages (from-to)100-103
Number of pages4
JournalHuman Immunology
Volume71
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • HLA alleles
  • Linkage disequilibrium
  • Olfactory receptor genes
  • Smell preferences

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