Sequence distribution of nucleobase adducts studied by isotope labeling of DNA–MASS spectrometry

Natalia Y Tretyakova

doi:10.1201/9781420044034

Sequence distribution of nucleobase adducts studied by isotope labeling of DNA–MASS spectrometry

Natalia Y Tretyakova

Medicinal Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

The formation of covalent nucleobase lesions (DNA adducts) is the first critical step of chemical carcinogenesis.¹ If not repaired, DNA adducts can cause mispairing during DNA replication and be converted to heritable mutations. Accumulation of genetic changes in tumor suppressor genes and protooncogenes is a hallmark of cancer.²

Original language	English (US)
Title of host publication	Mass Spectrometry of Nucleosides and Nucleic Acids
Publisher	CRC Press
Pages	257-282
Number of pages	26
ISBN (Electronic)	9781420044034
ISBN (Print)	9781420044027
DOIs	https://doi.org/10.1201/9781420044034
State	Published - Jan 1 2009

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title = "Sequence distribution of nucleobase adducts studied by isotope labeling of DNA–MASS spectrometry",

abstract = "The formation of covalent nucleobase lesions (DNA adducts) is the first critical step of chemical carcinogenesis.1 If not repaired, DNA adducts can cause mispairing during DNA replication and be converted to heritable mutations. Accumulation of genetic changes in tumor suppressor genes and protooncogenes is a hallmark of cancer.2 ",

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AB - The formation of covalent nucleobase lesions (DNA adducts) is the first critical step of chemical carcinogenesis.1 If not repaired, DNA adducts can cause mispairing during DNA replication and be converted to heritable mutations. Accumulation of genetic changes in tumor suppressor genes and protooncogenes is a hallmark of cancer.2

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BT - Mass Spectrometry of Nucleosides and Nucleic Acids

PB - CRC Press

ER -

Sequence distribution of nucleobase adducts studied by isotope labeling of DNA–MASS spectrometry

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