Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression

Alexa A Pragman, Lisa Herron-Olson, Laura C. Case, Sara M. Vetter, Evan E. Henke, Vivek Kapur, Patrick M. Schlievert

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Abstract

The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.

Original languageEnglish (US)
Pages (from-to)7515-7519
Number of pages5
JournalJournal of bacteriology
Volume189
Issue number20
DOIs
StatePublished - Oct 2007

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    Pragman, A. A., Herron-Olson, L., Case, L. C., Vetter, S. M., Henke, E. E., Kapur, V., & Schlievert, P. M. (2007). Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression. Journal of bacteriology, 189(20), 7515-7519. https://doi.org/10.1128/JB.00547-07