Sepsis-Induced Tissue Hypoperfusion

Alan E. Jones, Michael A. Puskarich

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


Sepsis affects the cardiovascular system through multiple mechanisms, and often these derangements result in tissue hypoperfusion. Tissue hypoperfusion is often present in the setting of overt shock, but it can also be present in patients without obvious shock physiology. If left untreated, tissue hypoperfusion contributes to the development of multiple organ dysfunction and, ultimately, death. Therefore, it is critical for the clinician to understand the pathophysiology, recognition, and treatment of sepsis-induced hypoperfusion.

Original languageEnglish (US)
Pages (from-to)769-779
Number of pages11
JournalCritical Care Clinics
Issue number4
StatePublished - Oct 2009
Externally publishedYes

Bibliographical note

Copyright 2010 Elsevier B.V., All rights reserved.


  • Emergency
  • Hypoperfusion
  • Infection
  • Lactate
  • Resuscitation
  • Sepsis
  • Septic shock


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