Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets

Mohammad Heidarian, Thomas S. Griffith, Vladimir P. Badovinac

Research output: Contribution to journalShort surveypeer-review

6 Scopus citations

Abstract

Formation of long-lasting memory lymphocytes is one of the foundational characteristics of adaptive immunity and the basis of many vaccination strategies. Following the rapid expansion and contraction of effector CD8 T cells, the surviving antigen (Ag)-specific cells give rise to the memory CD8 T cells that persist for a long time and are phenotypically and functionally distinct from their naïve counterparts. Significant heterogeneity exists within the memory CD8 T cell pool, as different subsets display distinct tissue localization preferences, cytotoxic ability, and proliferative capacity, but all memory CD8 T cells are equipped to mount an enhanced immune response upon Ag re-encounter. Memory CD8 T cells demonstrate numerical stability under homeostatic conditions, but sepsis causes a significant decline in the number of memory CD8 T cells and diminishes their Ag-dependent and -independent functions. Sepsis also rewires the transcriptional profile of memory CD8 T cells, which profoundly impacts memory CD8 T cell differentiation and, ultimately, the protective capacity of memory CD8 T cells upon subsequent stimulation. This review delves into different aspects of memory CD8 T cell subsets as well as the immediate and long-term impact of sepsis on memory CD8 T cell biology.

Original languageEnglish (US)
Article number1130009
JournalFrontiers in immunology
Volume14
DOIs
StatePublished - Jan 23 2023

Bibliographical note

Funding Information:
Supported by NIH Grants GM134880, AI114543 (V.P.B.), R35GM140881 (T.S.G.). The Holden Comprehensive Cancer Center at The University of Iowa and its National Cancer Institute Award P30CA086862 (V.P.B) and a Department of Veterans Affairs Merit Review Award I01BX001324 (T.S.G.). T.S.G. is the recipient of a Research Career Scientist award (IK6BX006192) from the Department of Veterans Affairs. V.P.B. is a University of Iowa Distinguished Scholar. Acknowledgments

Funding Information:
Supported by NIH Grants GM134880, AI114543 (V.P.B.), R35GM140881 (T.S.G.). The Holden Comprehensive Cancer Center at The University of Iowa and its National Cancer Institute Award P30CA086862 (V.P.B) and a Department of Veterans Affairs Merit Review Award I01BX001324 (T.S.G.). T.S.G. is the recipient of a Research Career Scientist award (IK6BX006192) from the Department of Veterans Affairs. V.P.B. is a University of Iowa Distinguished Scholar.

Publisher Copyright:
Copyright © 2023 Heidarian, Griffith and Badovinac.

Keywords

  • CD8 T cell
  • Immunoparalysis
  • composition
  • differentiation
  • function
  • memory
  • sepsis

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

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