Sepsis and multiple sclerosis: Causative links and outcomes

Đorđe Miljković, Suzana Stanisavljević, Isaac J. Jensen, Thomas S. Griffith, Vladimir P. Badovinac

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Sepsis is a life-threatening condition characterized by an acute cytokine storm followed by prolonged dysfunction of the immune system in the survivors. Post-septic lymphopenia and functional deficits of the remaining immune cells lead to increased susceptibility to secondary infections and other morbid conditions causing late death in the patients. This state of post-septic immunoparalysis may also influence disorders stemming from inappropriate or overactive immune responses, such as autoimmune and immunoinflammatory diseases, including multiple sclerosis. In addition, ongoing autoimmunity likely influences the susceptibility to and outcome of sepsis. This review article addresses the bidirectional relationship between sepsis and multiple sclerosis, with a focus on the immunologic mechanisms of the interaction and potential directions for future studies.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalImmunology Letters
Volume238
DOIs
StatePublished - Oct 1 2021

Bibliographical note

Funding Information:
This work was supported by Ministry of Education, Science and Technological Development of Republic of Serbia #451-03-9/2021-14/200007 (Đ.M., S.S.), Science Fund of the Republic of Serbia, Serbian Science and Diaspora Collaboration Program #6409283 (Đ.M., V.P.B., S.S.), NIH Grants R01AI114543 (V.P.B.), R21AI147064 (V.P.B.), R35GM134880 (V.P.B.), R21AI151183 (V.P.B.), R01GM115462 (T.S.G.), R35GM140881 (T.S.G.), T32AI007511 (I.J.J.), T32AI007485 (I.J.J.) and a Veterans Health Administration Merit Review Award I01BX001324 (T.S.G.).

Publisher Copyright:
© 2021

Keywords

  • Gut microbiota
  • Multiple sclerosis
  • Sepsis

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