Abstract
Zirconia particles are a very robust material and have received considerable attention as a stationary phase support for HPLC. Chromatographic performances of ADMPC- and CDMPC-coated zirconia as chiral stationary phases (CSPs) were compared by measuring the chiral discrimination of a set of 14 racemic compounds on the two columns. On the whole CDMPC-zirconia showed better chiral selectivity for the test compounds than ADMPC-zirconia. The two CSPs show complementary chiral recognition capability for the types of racemates studied. Chiral selectivities of ADMPC- and CDMPC-coated zirconia were also compared with those of ADMPC- and CDMPC-coated silica. The zirconia CSPs exhibited comparable and sometimes better enantioselectivity than the corresponding silica CSPs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1331-1336 |
| Number of pages | 6 |
| Journal | Journal of Separation Science |
| Volume | 26 |
| Issue number | 15-16 |
| DOIs | |
| State | Published - Oct 2003 |
Keywords
- Amylose and cellulose tris(3,5-dimethylphenylcarbamate)
- Chiral stationary phase
- HPLC
- Zirconia
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