Zirconia particles are a very robust material and have received considerable attention as a stationary phase support for HPLC. Chromatographic performances of ADMPC- and CDMPC-coated zirconia as chiral stationary phases (CSPs) were compared by measuring the chiral discrimination of a set of 14 racemic compounds on the two columns. On the whole CDMPC-zirconia showed better chiral selectivity for the test compounds than ADMPC-zirconia. The two CSPs show complementary chiral recognition capability for the types of racemates studied. Chiral selectivities of ADMPC- and CDMPC-coated zirconia were also compared with those of ADMPC- and CDMPC-coated silica. The zirconia CSPs exhibited comparable and sometimes better enantioselectivity than the corresponding silica CSPs.
- Amylose and cellulose tris(3,5-dimethylphenylcarbamate)
- Chiral stationary phase