Separation of racemic compounds on amylose and cellulose dimethylphenylcarbamate-coated zirconia in HPLC

Jung Hag Park, Young Chul Whang, Yun Jung Jung, Yoshio Okamoto, Chiyo Yamamoto, Peter W. Carr, Clayton V. McNeff

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Zirconia particles are a very robust material and have received considerable attention as a stationary phase support for HPLC. Chromatographic performances of ADMPC- and CDMPC-coated zirconia as chiral stationary phases (CSPs) were compared by measuring the chiral discrimination of a set of 14 racemic compounds on the two columns. On the whole CDMPC-zirconia showed better chiral selectivity for the test compounds than ADMPC-zirconia. The two CSPs show complementary chiral recognition capability for the types of racemates studied. Chiral selectivities of ADMPC- and CDMPC-coated zirconia were also compared with those of ADMPC- and CDMPC-coated silica. The zirconia CSPs exhibited comparable and sometimes better enantioselectivity than the corresponding silica CSPs.

Original languageEnglish (US)
Pages (from-to)1331-1336
Number of pages6
JournalJournal of Separation Science
Volume26
Issue number15-16
DOIs
StatePublished - Oct 1 2003

Keywords

  • Amylose and cellulose tris(3,5-dimethylphenylcarbamate)
  • Chiral stationary phase
  • HPLC
  • Zirconia

Fingerprint Dive into the research topics of 'Separation of racemic compounds on amylose and cellulose dimethylphenylcarbamate-coated zirconia in HPLC'. Together they form a unique fingerprint.

  • Cite this