Separation of racemic 2,4-dinitrophenyl amino acids on carboxymethyl-β-cyclodextrin coated zirconia in RPLC

Sung Yeh Park, Jung Kon Park, Jung Hag Park, Clayton V. McNeff, Peter W. Carr

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

We report preparation and use of carboxymethyl-β-cyclodextrin-coated zirconia as a chiral stationary phase (CSP) for separation of enantiomers of 2,4-dinitrophenyl (DNP) amino acids in reversed-phase high performance liquid chromatography. The CSP showed good enantioselectivity for some of the amino acids studied. Effects of pH and amount of methanol in mobile phases on retention and enantioselectivity for the analytes were examined.

Original languageEnglish (US)
Pages (from-to)179-185
Number of pages7
JournalMicrochemical Journal
Volume70
Issue number3
DOIs
StatePublished - 2001

Bibliographical note

Funding Information:
This work was supported in part by a grant from the Korea Science and Engineering Foundation (2000-2-12400-001-3), in part by a grant from the Korea Research Foundation (1998-015-D00294) and in part by a grant from Yeungnam University (1999).

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

  • Carboxymethyl-β-cyclodextrin-coated zirconia
  • Chiral stationary phase, LC
  • RPLC separation
  • Racemic DNP-amino acids

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