Separation of racemic 2,4-dinitrophenyl amino acids on 9-O- (phenyloxycarbonyl)quinine-bonded carbon-clad zirconia in reversed-phase liquid chromatography

Jung Hag Park, Joon Woo Lee, Sang Hyun Kwon, Jin Soon Cha, Peter W. Carr, Clayton V. McNeff

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Zirconia is known to be one of the best materials for the chromatographic support due to its excellent chemical, thermal, and mechanical stability. In this work, we report preparation and use of 9-O-(phenyloxycarbonyl)quinine- bonded carbon-clad zirconia (QNCZ) as a chiral stationary phase (CSP) for separation of N-(2,4-dinitrophenyl) (DNP)-amino acids (AAs) enantiomers in reversed-phase liquid chromatography. Retention and enantioselectivity of the QNCZ CSP were compared with those of quinine 3-triethoxysilylpropylcarbamate- coated zirconia (QNZ) and quinine 3-triethoxysilylpropylcarbamate-bonded silica (QNS). The QNCZ CSP showed in general the better enantioselectivity for most of the amino acids studied.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalJournal of Chromatography A
Volume1050
Issue number2
DOIs
StatePublished - Oct 1 2004

Keywords

  • 9-O-(Phenyloxycarbonyl) quinine
  • Carbon-clad zirconia
  • Chiral stationary phases
  • DNP-amino acids
  • Enantiomer separation

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