Separation of racemic 2,4-dinitrophenyl amino acids on 9-O- (phenyloxycarbonyl)quinine-bonded carbon-clad zirconia in reversed-phase liquid chromatography

Jung Hag Park; Joon Woo Lee; Sang Hyun Kwon; Jin Soon Cha; Peter W. Carr; Clayton V. McNeff

doi:10.1016/j.chroma.2004.08.027

Separation of racemic 2,4-dinitrophenyl amino acids on 9-O- (phenyloxycarbonyl)quinine-bonded carbon-clad zirconia in reversed-phase liquid chromatography

Jung Hag Park, Joon Woo Lee, Sang Hyun Kwon, Jin Soon Cha, Peter W. Carr, Clayton V. McNeff

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Zirconia is known to be one of the best materials for the chromatographic support due to its excellent chemical, thermal, and mechanical stability. In this work, we report preparation and use of 9-O-(phenyloxycarbonyl)quinine- bonded carbon-clad zirconia (QNCZ) as a chiral stationary phase (CSP) for separation of N-(2,4-dinitrophenyl) (DNP)-amino acids (AAs) enantiomers in reversed-phase liquid chromatography. Retention and enantioselectivity of the QNCZ CSP were compared with those of quinine 3-triethoxysilylpropylcarbamate- coated zirconia (QNZ) and quinine 3-triethoxysilylpropylcarbamate-bonded silica (QNS). The QNCZ CSP showed in general the better enantioselectivity for most of the amino acids studied.

Original language	English (US)
Pages (from-to)	151-157
Number of pages	7
Journal	Journal of Chromatography A
Volume	1050
Issue number	2
DOIs	https://doi.org/10.1016/j.chroma.2004.08.027
State	Published - Oct 1 2004

Keywords

9-O-(Phenyloxycarbonyl) quinine
Carbon-clad zirconia
Chiral stationary phases
DNP-amino acids
Enantiomer separation

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10.1016/j.chroma.2004.08.027

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title = "Separation of racemic 2,4-dinitrophenyl amino acids on 9-O- (phenyloxycarbonyl)quinine-bonded carbon-clad zirconia in reversed-phase liquid chromatography",

abstract = "Zirconia is known to be one of the best materials for the chromatographic support due to its excellent chemical, thermal, and mechanical stability. In this work, we report preparation and use of 9-O-(phenyloxycarbonyl)quinine- bonded carbon-clad zirconia (QNCZ) as a chiral stationary phase (CSP) for separation of N-(2,4-dinitrophenyl) (DNP)-amino acids (AAs) enantiomers in reversed-phase liquid chromatography. Retention and enantioselectivity of the QNCZ CSP were compared with those of quinine 3-triethoxysilylpropylcarbamate- coated zirconia (QNZ) and quinine 3-triethoxysilylpropylcarbamate-bonded silica (QNS). The QNCZ CSP showed in general the better enantioselectivity for most of the amino acids studied.",

keywords = "9-O-(Phenyloxycarbonyl) quinine, Carbon-clad zirconia, Chiral stationary phases, DNP-amino acids, Enantiomer separation",

author = "Park, {Jung Hag} and Lee, {Joon Woo} and Kwon, {Sang Hyun} and Cha, {Jin Soon} and Carr, {Peter W.} and McNeff, {Clayton V.}",

year = "2004",

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day = "1",

doi = "10.1016/j.chroma.2004.08.027",

language = "English (US)",

volume = "1050",

pages = "151--157",

journal = "Journal of Chromatography A",

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T1 - Separation of racemic 2,4-dinitrophenyl amino acids on 9-O- (phenyloxycarbonyl)quinine-bonded carbon-clad zirconia in reversed-phase liquid chromatography

AU - Park, Jung Hag

AU - Lee, Joon Woo

AU - Kwon, Sang Hyun

AU - Cha, Jin Soon

AU - Carr, Peter W.

AU - McNeff, Clayton V.

PY - 2004/10/1

Y1 - 2004/10/1

N2 - Zirconia is known to be one of the best materials for the chromatographic support due to its excellent chemical, thermal, and mechanical stability. In this work, we report preparation and use of 9-O-(phenyloxycarbonyl)quinine- bonded carbon-clad zirconia (QNCZ) as a chiral stationary phase (CSP) for separation of N-(2,4-dinitrophenyl) (DNP)-amino acids (AAs) enantiomers in reversed-phase liquid chromatography. Retention and enantioselectivity of the QNCZ CSP were compared with those of quinine 3-triethoxysilylpropylcarbamate- coated zirconia (QNZ) and quinine 3-triethoxysilylpropylcarbamate-bonded silica (QNS). The QNCZ CSP showed in general the better enantioselectivity for most of the amino acids studied.

AB - Zirconia is known to be one of the best materials for the chromatographic support due to its excellent chemical, thermal, and mechanical stability. In this work, we report preparation and use of 9-O-(phenyloxycarbonyl)quinine- bonded carbon-clad zirconia (QNCZ) as a chiral stationary phase (CSP) for separation of N-(2,4-dinitrophenyl) (DNP)-amino acids (AAs) enantiomers in reversed-phase liquid chromatography. Retention and enantioselectivity of the QNCZ CSP were compared with those of quinine 3-triethoxysilylpropylcarbamate- coated zirconia (QNZ) and quinine 3-triethoxysilylpropylcarbamate-bonded silica (QNS). The QNCZ CSP showed in general the better enantioselectivity for most of the amino acids studied.

KW - 9-O-(Phenyloxycarbonyl) quinine

KW - Carbon-clad zirconia

KW - Chiral stationary phases

KW - DNP-amino acids

KW - Enantiomer separation

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DO - 10.1016/j.chroma.2004.08.027

M3 - Article

C2 - 15508307

AN - SCOPUS:4644224488

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VL - 1050

SP - 151

EP - 157

JO - Journal of Chromatography A

JF - Journal of Chromatography A

IS - 2

ER -

Separation of racemic 2,4-dinitrophenyl amino acids on 9-O- (phenyloxycarbonyl)quinine-bonded carbon-clad zirconia in reversed-phase liquid chromatography

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