Sentinel Lymph Node Biopsy in Melanoma: Overview and Updates

  • Adrian Mansini
  • , Shah Aarohi
  • , Mario Della Mura
  • , Joana Sorino
  • , Gerardo Cazzato
  • , Alessio Giubellino

Research output: Contribution to journalReview articlepeer-review

Abstract

The role of regional lymph nodes in melanoma metastasis has long been recognized. This review will detail the evolving role of sentinel lymph node biopsy (SLNB) in melanoma management in the era of adjuvant therapies. We analyze key themes and findings from recent publications, highlighting both areas of consensus and ongoing controversies. While the landscape of melanoma management continues to evolve with the advent of novel therapeutic combinations, SLNB remains a valuable tool for staging and potentially provides therapeutic benefit. However, optimal patient selection for SLNB requires careful consideration of individual risk factors and benefits of adjuvant therapy.

Original languageEnglish (US)
Article number9469
JournalInternational journal of molecular sciences
Volume26
Issue number19
DOIs
StatePublished - Oct 2025

Bibliographical note

Publisher Copyright:
© 2025 by the authors.

Keywords

  • biopsy
  • melanoma
  • metastasis
  • sentinel lymph node

PubMed: MeSH publication types

  • Journal Article
  • Review

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