Sensorineural hearing loss in antigen-induced otitis media

Chinchillas were sensitized with human serum albumin (HSA). When circulating antibody titers were sufficiently elevated as to induce local inflammation, 1 ml of HSA (50, 5, 0.5 mg/ml) was instilled into the left middle-ear cavity from the superior bulla. HSA containing a steroid agent was instilled into the right ear. Non-sensitized animals were used as control. In the sensitized animals, a significant hearing loss occurred at higher frequencies. The loss was dose related. Less severe hearing loss was found following steroid treatment. We conclude that sensorineural hearing loss can occur in antigen-induced otitis media.