Abstract
Chinchillas were sensitized with human serum albumin (HSA). When circulating antibody-titers were sufficiently elevated as to induce local inflammation, 1 ml of HSA (50, 5, 0.5 mg/ ml) was instilled into the left middle ear cavity from the superior bulla. HSA containing a steroid agent was instilled into the right ear. Non-sensitized animals were used as control. In the sensitized animals, a significant hearing loss occurred at higher frequencies. The loss was dose-related. Less severe hearing loss was found following steroid treatment. We conclude that sensorineural hearing loss can occur in antigen-induced otitis media.
Original language | English (US) |
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Pages (from-to) | 67-72 |
Number of pages | 6 |
Journal | Acta Oto-Laryngologica |
Volume | 105 |
Issue number | S457 |
DOIs | |
State | Published - 1988 |
Bibliographical note
Funding Information:This research was supported by NINCDS Grant NS-14538 for the Otitis Media Pathogenesis Program Project.
Keywords
- Arthus otitis media
- Chinchilla
- Sensorineural hearing loss
- Steroid treatment