Sensorineural hearing loss in antigen-induced otitis media

Tetsuo Morizono, Yukiyoshi Hamaguchi, Steven S Juhn

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Chinchillas were sensitized with human serum albumin (HSA). When circulating antibody-titers were sufficiently elevated as to induce local inflammation, 1 ml of HSA (50, 5, 0.5 mg/ ml) was instilled into the left middle ear cavity from the superior bulla. HSA containing a steroid agent was instilled into the right ear. Non-sensitized animals were used as control. In the sensitized animals, a significant hearing loss occurred at higher frequencies. The loss was dose-related. Less severe hearing loss was found following steroid treatment. We conclude that sensorineural hearing loss can occur in antigen-induced otitis media.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalActa Oto-Laryngologica
Issue numberS457
StatePublished - 1988

Bibliographical note

Funding Information:
This research was supported by NINCDS Grant NS-14538 for the Otitis Media Pathogenesis Program Project.


  • Arthus otitis media
  • Chinchilla
  • Sensorineural hearing loss
  • Steroid treatment


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