Sensitization of nociceptors and dorsal horn neurons contributes to pain in sickle cell disease

Megan L. Uhelski, Donald A Simone

Research output: Contribution to journalReview article

Abstract

Sickle cell disease (SCD) describes a group of disorders associated with a point mutation in the beta chain of hemoglobin. The mutation leads to the creation of sickle hemoglobin (HbS) and causes distortion of erythrocytes through polymerization under low oxygen, resulting in characteristic sickle red blood cells. Vaso-occlusion episodes caused by accumulation of sRBCs results in ischemia-reperfusion injury, reduced oxygen supply to organs, oxidative stress, organ damage and severe pain that often requires hospitalization and opioid treatment. Further, many patients suffer from chronic pain, including hypersensitivity to heat and cold stimuli. Progress towards the development of novel strategies for both acute and chronic pain in patients with SCD has been impeded by a lack of understanding the mechanisms underlying pain in SCD. The purpose of this review is to highlight evidence for the contribution of peripheral and central sensitization that leads to widespread, chronic pain and hyperalgesia. Targeting the mechanisms that initiate and maintain sensitization in SCD might offer effective approaches to manage the severe and debilitating pain associated with this condition.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalNeuroscience Letters
Volume705
DOIs
StatePublished - Jul 13 2019

Fingerprint

Posterior Horn Cells
Nociceptors
Sickle Cell Anemia
Chronic Pain
Pain
Erythrocytes
Oxygen
Central Nervous System Sensitization
Sickle Hemoglobin
Hyperalgesia
Acute Pain
Reperfusion Injury
Point Mutation
Polymerization
Opioid Analgesics
Hypersensitivity
Hemoglobins
Hospitalization
Oxidative Stress
Hot Temperature

Keywords

  • Central sensitization
  • Hyperalgesia
  • Nociceptor sensitization
  • Sickle cell disease

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, N.I.H., Extramural

Cite this

Sensitization of nociceptors and dorsal horn neurons contributes to pain in sickle cell disease. / Uhelski, Megan L.; Simone, Donald A.

In: Neuroscience Letters, Vol. 705, 13.07.2019, p. 20-26.

Research output: Contribution to journalReview article

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N2 - Sickle cell disease (SCD) describes a group of disorders associated with a point mutation in the beta chain of hemoglobin. The mutation leads to the creation of sickle hemoglobin (HbS) and causes distortion of erythrocytes through polymerization under low oxygen, resulting in characteristic sickle red blood cells. Vaso-occlusion episodes caused by accumulation of sRBCs results in ischemia-reperfusion injury, reduced oxygen supply to organs, oxidative stress, organ damage and severe pain that often requires hospitalization and opioid treatment. Further, many patients suffer from chronic pain, including hypersensitivity to heat and cold stimuli. Progress towards the development of novel strategies for both acute and chronic pain in patients with SCD has been impeded by a lack of understanding the mechanisms underlying pain in SCD. The purpose of this review is to highlight evidence for the contribution of peripheral and central sensitization that leads to widespread, chronic pain and hyperalgesia. Targeting the mechanisms that initiate and maintain sensitization in SCD might offer effective approaches to manage the severe and debilitating pain associated with this condition.

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