Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin

Donald A. Simone, Thomas K. Baumann, J. G. Collins, Robert H. LaMotte

Research output: Contribution to journalArticle

122 Scopus citations

Abstract

Intradermal injection of 100 μg of capsaicin in cats excited dorsal horn spinal neurons classified as either 'high threshold' or 'wide dynamic range'. Capsaicin enhanced their responses to innocuous mechanical stimulation. A role for these neurons in mechanical hyperalgesia is suggested.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalBrain Research
Volume486
Issue number1
DOIs
StatePublished - May 1 1989

Keywords

  • Capsaicin
  • Dorsal horn neuron
  • Mechanical hyperalgesia
  • Pain

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