Intradermal injection of 100 μg of capsaicin in cats excited dorsal horn spinal neurons classified as either 'high threshold' or 'wide dynamic range'. Capsaicin enhanced their responses to innocuous mechanical stimulation. A role for these neurons in mechanical hyperalgesia is suggested.
Bibliographical noteFunding Information:
Supported in part by NIH Training Grant NS-07968 (to D.A.S.) and NIH Grants NS-14624 (to R.H.L.) and NS-23033 (to J.G.C.).
- Dorsal horn neuron
- Mechanical hyperalgesia