Sensitivity of single-voxel 1H-MRS in investigating the metabolism of the activated human visual cortex at 7 T

Silvia Mangia, Ivan Tkáč, Rolf Gruetter, Pierre Francois Van De Moortele, Federico Giove, Bruno Maraviglia, Kâmil Uǧurbil

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102 Scopus citations


Proton magnetic resonance spectroscopy (1H-MRS) has been used in a number of studies to noninvasively assess the temporal changes of lactate in the activated human brain. However, the results have not been consistent. The aim of the present study was to test the sensitivity of 1H-MRS during functional experiments at the highest magnetic field currently available for human studies (7 T). Stability and reproducibility of the measurements were evaluated from LCModel analysis of time series of spectra measured during a visual stimulation paradigm and by examination of the difference between spectra obtained at rest and during activation. The sensitivity threshold to detect concentration changes was 0.2 μmol/g for most of the quantified metabolites. The possible variations of metabolite concentrations during visual stimulation were within the same range (±0.2 μmol/g). In addition, the influence of a small line-narrowing effect due to the blood oxygenation level-dependent (BOLD) T2* changes on the estimated concentrations was simulated. Quantification of metabolites was, in general, not affected beyond 1% by line-width changes within 0.5 Hz.

Original languageEnglish (US)
Pages (from-to)343-348
Number of pages6
JournalMagnetic Resonance Imaging
Issue number4
StatePublished - May 2006

Bibliographical note

Funding Information:
This study was supported by grants NIH P41RR08079 and R01NS38672, the Keck Foundation and Mind Institute.


  • BOLD
  • Lactate
  • Single-voxel proton spectroscopy
  • Ultrahigh magnetic field


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