Abstract
Proton magnetic resonance spectroscopy (1H-MRS) has been used in a number of studies to noninvasively assess the temporal changes of lactate in the activated human brain. However, the results have not been consistent. The aim of the present study was to test the sensitivity of 1H-MRS during functional experiments at the highest magnetic field currently available for human studies (7 T). Stability and reproducibility of the measurements were evaluated from LCModel analysis of time series of spectra measured during a visual stimulation paradigm and by examination of the difference between spectra obtained at rest and during activation. The sensitivity threshold to detect concentration changes was 0.2 μmol/g for most of the quantified metabolites. The possible variations of metabolite concentrations during visual stimulation were within the same range (±0.2 μmol/g). In addition, the influence of a small line-narrowing effect due to the blood oxygenation level-dependent (BOLD) T2* changes on the estimated concentrations was simulated. Quantification of metabolites was, in general, not affected beyond 1% by line-width changes within 0.5 Hz.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 343-348 |
| Number of pages | 6 |
| Journal | Magnetic Resonance Imaging |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 1 2006 |
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Keywords
- BOLD
- Lactate
- Single-voxel proton spectroscopy
- Ultrahigh magnetic field
Cite this
Sensitivity of single-voxel 1H-MRS in investigating the metabolism of the activated human visual cortex at 7 T. / Mangia, Silvia; Tkáč, Ivan; Gruetter, Rolf; Van De Moortele, Pierre Francois; Giove, Federico; Maraviglia, Bruno; Uǧurbil, Kâmil.
In: Magnetic Resonance Imaging, Vol. 24, No. 4, 01.05.2006, p. 343-348.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sensitivity of single-voxel 1H-MRS in investigating the metabolism of the activated human visual cortex at 7 T
AU - Mangia, Silvia
AU - Tkáč, Ivan
AU - Gruetter, Rolf
AU - Van De Moortele, Pierre Francois
AU - Giove, Federico
AU - Maraviglia, Bruno
AU - Uǧurbil, Kâmil
PY - 2006/5/1
Y1 - 2006/5/1
N2 - Proton magnetic resonance spectroscopy (1H-MRS) has been used in a number of studies to noninvasively assess the temporal changes of lactate in the activated human brain. However, the results have not been consistent. The aim of the present study was to test the sensitivity of 1H-MRS during functional experiments at the highest magnetic field currently available for human studies (7 T). Stability and reproducibility of the measurements were evaluated from LCModel analysis of time series of spectra measured during a visual stimulation paradigm and by examination of the difference between spectra obtained at rest and during activation. The sensitivity threshold to detect concentration changes was 0.2 μmol/g for most of the quantified metabolites. The possible variations of metabolite concentrations during visual stimulation were within the same range (±0.2 μmol/g). In addition, the influence of a small line-narrowing effect due to the blood oxygenation level-dependent (BOLD) T2* changes on the estimated concentrations was simulated. Quantification of metabolites was, in general, not affected beyond 1% by line-width changes within 0.5 Hz.
AB - Proton magnetic resonance spectroscopy (1H-MRS) has been used in a number of studies to noninvasively assess the temporal changes of lactate in the activated human brain. However, the results have not been consistent. The aim of the present study was to test the sensitivity of 1H-MRS during functional experiments at the highest magnetic field currently available for human studies (7 T). Stability and reproducibility of the measurements were evaluated from LCModel analysis of time series of spectra measured during a visual stimulation paradigm and by examination of the difference between spectra obtained at rest and during activation. The sensitivity threshold to detect concentration changes was 0.2 μmol/g for most of the quantified metabolites. The possible variations of metabolite concentrations during visual stimulation were within the same range (±0.2 μmol/g). In addition, the influence of a small line-narrowing effect due to the blood oxygenation level-dependent (BOLD) T2* changes on the estimated concentrations was simulated. Quantification of metabolites was, in general, not affected beyond 1% by line-width changes within 0.5 Hz.
KW - BOLD
KW - Lactate
KW - Single-voxel proton spectroscopy
KW - Ultrahigh magnetic field
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U2 - 10.1016/j.mri.2005.12.023
DO - 10.1016/j.mri.2005.12.023
M3 - Article
C2 - 16677939
AN - SCOPUS:33646141580
VL - 24
SP - 343
EP - 348
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
IS - 4
ER -