Sensitivity of osteosarcoma cells to HDAC inhibitor AR-42 mediated apoptosis

Keyphrases

• Acid Activation 12%
• AKT Pathway 25%
• Akt Phosphorylation 12%
• Anticancer Agents 12%
• Apoptosis 100%
• Apoptotic Activity 12%
• Apoptotic Response 12%
• AR-42 100%
• Cancer Causes 12%
• Cancer Mortality 12%
• Canine Osteosarcoma 37%
• Caspase Cleavage 12%
• Caspase-3 25%
• Cell Survival 12%
• Cell Viability 37%
• Chemotherapeutic Interventions 12%
• Chemotherapy 12%
• Current Therapies 12%
• Downstream Signaling 12%
• Doxorubicin 25%
• Doxorubicin Treatments 12%
• Drug-induced Apoptosis 12%
• Enzymatic Activity 12%
• Histone Acetylation 12%
• Histone Deacetylase Activity 12%
• Histone Deacetylase Inhibitor (HDACi) 100%
• Human Osteosarcoma 25%
• Human Osteosarcoma Cells 12%
• Induced Cell Death 12%
• Inhibitor Treatment 12%
• Intrinsic Mitochondrial Pathway 12%
• Large Animal Model 12%
• Limb-sparing Surgery 12%
• Older Adults 12%
• Osteoblast 12%
• Osteosarcoma 37%
• Osteosarcoma Cell Lines 12%
• Osteosarcoma Cells 100%
• Pet Dogs 12%
• Pleiotropic Effects 12%
• Potent Inhibitor 25%
• Preclinical Evaluation 12%
• Primary Bone Tumor 12%
• Real Need 12%
• Signaling Molecules 12%
• Suberoylanilide Hydroxamic Acid 37%
• Survival Signaling 12%
• Synergistic Effect 12%
• Western Blotting 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Anticancer Drug 12%
• Bone Cancer 12%
• Bone Tumor 12%
• Caspase 12%
• Caspase 3 25%
• Cell Viability 37%
• Chemotherapy 12%
• Doxorubicin 37%
• Fluorescence Activated Cell Sorting 12%
• Histone 12%
• Histone Deacetylase 25%
• Histone Deacetylase Inhibitor 100%
• Malignant Neoplasm 12%
• Osteosarcoma 100%
• Pet Animal 12%
• Vorinostat 37%
• Western Blot 12%

Veterinary Science and Veterinary Medicine

• Bone Tumor 14%
• Cancer 14%
• Canine Osteosarcoma 14%
• Dog 28%
• Doxorubicin 42%
• Limb Sparing 14%
• Osteoblast 14%
• Osteosarcoma 100%
• Pet Animal 14%
• Primary Bone 14%