TY - JOUR
T1 - Sensitivity and specificity of ADH as a biochemical marker in alcohol- dependence
T2 - Indian context
AU - Vaswani, Meera
AU - Desai, N. G.
PY - 1999/12/1
Y1 - 1999/12/1
N2 - A variety of laboratory tests are available to assist in the diagnosis of alcoholism and related disorders. Alcohol dehydrogenase (ADH), being the rate-limiting enzyme in alcohol metabolism, has been used in the present study to assess its sensitivity and specificity with respect to other liver enzymes. Fifty-two alcohol-dependent subjects were studied along with 52 normal healthy controls for liver function tests (GGT, GPT, GOT and ADH). Discriminative analysis using the BMDP program showed that the sensitivity range of the liver enzymes was between 60-70% when compared with specificity range of 85-100%. On performance measures using GGT as a standard, ADH was found to have good sensitivity, but poor specificity. Thus, ADH alone cannot be used as a biochemical marker of alcoholism.
AB - A variety of laboratory tests are available to assist in the diagnosis of alcoholism and related disorders. Alcohol dehydrogenase (ADH), being the rate-limiting enzyme in alcohol metabolism, has been used in the present study to assess its sensitivity and specificity with respect to other liver enzymes. Fifty-two alcohol-dependent subjects were studied along with 52 normal healthy controls for liver function tests (GGT, GPT, GOT and ADH). Discriminative analysis using the BMDP program showed that the sensitivity range of the liver enzymes was between 60-70% when compared with specificity range of 85-100%. On performance measures using GGT as a standard, ADH was found to have good sensitivity, but poor specificity. Thus, ADH alone cannot be used as a biochemical marker of alcoholism.
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M3 - Article
AN - SCOPUS:0033499139
SN - 1080-8388
VL - 20
SP - 135
EP - 140
JO - Research Communications in Alcohol and Substances of Abuse
JF - Research Communications in Alcohol and Substances of Abuse
IS - 3-4
ER -