Sensitivity analysis of periprosthetic healing to cell migration, growth factor and post-operative gap using a mechanobiological model

Pascal Swider, D. Ambard, G. Guérin, Kjeld Søballe, Joan E. Bechtold

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A theoretical rationale, which could help in the investigation of mechanobiological factors affecting periprosthetic tissue healing, is still an open problem. We used a parametric sensitivity analysis to extend a theoretical model based on reactive transport and computational cell biology. The numerical experimentation involved the drill hole, the haptotactic and chemotactic migrations, and the initial concentration of an anabolic growth factor. Output measure was the mineral fraction in tissue surrounding a polymethymethacrylate (PMMA) canine implant (stable loaded implant, non-critical gap). Increasing growth factor concentration increased structural matrix synthesis. A cell adhesion gradient resulted in heterogeneous bone distribution and a growth factor gradient resulted in homogeneous bone distribution in the gap. This could explain the radial variation of bone density fromthe implant surface to the drill hole, indicating less secure fixation. This study helps to understand the relative importance of various host and clinical factors influencing bone distribution and resulting implant fixation.

Original languageEnglish (US)
Pages (from-to)763-771
Number of pages9
JournalComputer methods in biomechanics and biomedical engineering
Issue number9
StatePublished - 2011
Externally publishedYes

Bibliographical note

Funding Information:
The French Minister of Education and Research is acknowledged for its assistance. Related experimental studies were conducted with the support of NIH AR4205, Institute of Pathology at Aarhus University Hospital, Orthopaedic Research and Education Foundation, Danish Research Foundation for Health, Master of a guild, butcher Peter Ryholts Foundation and the Danish Rheumatism Association, and Anna and Jakob Jakobsens Foundation. Biomet donated the PMMA implants.


  • Anabolic growth factor
  • Computational cell biology
  • Implant fixation
  • Mechanobiology
  • Osteoblast
  • Reactive transport in porous media


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