Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

Henrique Borges da Silva, Changwei Peng, Haiguang Wang, Kelsey M. Wanhainen, Chaoyu Ma, Sharon Lopez, Alexander Khoruts, Nu Zhang, Stephen C. Jameson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Borges da Silva et al. report that the extracellular ATP receptor P2RX7 promotes generation of virus-specific tissue-resident memory (Trm) CD8+ T cells through induction of the TGF-β signaling pathway. Furthermore, long-term maintenance of Trm cells relies on continuous P2RX7 signaling.

Original languageEnglish (US)
Pages (from-to)158-171.e6
JournalImmunity
Volume53
Issue number1
DOIs
StatePublished - Jul 14 2020

Bibliographical note

Funding Information:
We thank Wanjun Chen (NIDCR) for providing the MiT-Tgfbr2 overexpression vector. We also thank the members of the Jamequist lab for critically reviewing the manuscript. S.C.J. was funded by NIAID ( R01 AI038903 and AI145147 ). H.B.d.S. was funded by NIAID ( K99/R00 AI139381 ) and a Paul C. Shiverick/CRI Irvington fellowship.

Funding Information:
We thank Wanjun Chen (NIDCR) for providing the MiT-Tgfbr2 overexpression vector. We also thank the members of the Jamequist lab for critically reviewing the manuscript. S.C.J. was funded by NIAID (R01 AI038903 and AI145147). H.B.d.S. was funded by NIAID (K99/R00 AI139381) and a Paul C. Shiverick/CRI Irvington fellowship. H.B.d.S. and S.C.J. conceived the project. H.B.d.S. and S.C.J. conceived the experiments. A.K. N.Z. and S.C.J. provided mice and reagents for all experiments. H.B.d.S. C.P. H.W. K.M.W. C.M. and S.L. performed the experiments and analyzed the data. H.B.d.S. and S.C.J. wrote the manuscript. The authors declare no competing interests.

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

  • P2RX7
  • TGF-β
  • eATP
  • memory CD8 T cells
  • non-lymphoid tissue

Fingerprint Dive into the research topics of 'Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8<sup>+</sup> Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β'. Together they form a unique fingerprint.

Cite this