Semisynthesis of the Neuroprotective Metabolite, Serofendic Acid

Szu Yi Hsu, Dimitri Perusse, Thomas Hougard, Michael J. Smanski

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Serofendic acid is a natural neuroprotective molecule found in fetal calf serum. It is able to protect neurons against mechanisms of cell death associated with neurodegenerative disease. Because only trace quantities are present in fetal calf serum and complete chemical syntheses are long and inefficient, its development as a therapeutic agent has been slow. We engineered a heterologous metabolic pathway in Streptomyces to produce a late-stage synthetic intermediate, ent-atiserenoic acid, at high titers. We completed the total synthesis of serofendic acid from this intermediate in four steps.

Original languageEnglish (US)
Pages (from-to)2397-2403
Number of pages7
JournalACS Synthetic Biology
Volume8
Issue number10
DOIs
StatePublished - Oct 18 2019

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Keywords

  • Streptomyces
  • metabolic engineering
  • neuroprotection
  • semisynthesis

PubMed: MeSH publication types

  • Journal Article
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't

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