Semisynthesis and biological evaluation of brevifoliol 13-[N-benzoyl-(-2′R,3′S)-3′-phenylisoserinate]

Gunda I. Georg; Zacharia S. Cheruvallath; David Vander Velde; Qing Mei Ye; Lester A. Mitscher; Richard H. Himes

doi:10.1016/S0960-894X(00)80346-7

Semisynthesis and biological evaluation of brevifoliol 13-[N-benzoyl-(-2′R,3′S)-3′-phenylisoserinate]

Gunda I. Georg
, Zacharia S. Cheruvallath
, David Vander Velde
, Qing Mei Ye
, Lester A. Mitscher
, Richard H. Himes

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Coupling between brevifoliol (1) and β-lactam (2) yielded, after protecting group removal, brevifoliol 13-[N-benzoyl-(2′R,3′S)-3′-phenylisoserinate] (3). This novel taxol analogue was found to be inactive in the microtubule binding assay and had little cytotoxicity against B16 melanoma cells.

Original language	English (US)
Pages (from-to)	1349-1350
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(00)80346-7
State	Published - Jun 1993

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title = "Semisynthesis and biological evaluation of brevifoliol 13-[N-benzoyl-(-2′R,3′S)-3′-phenylisoserinate]",

abstract = "Coupling between brevifoliol (1) and β-lactam (2) yielded, after protecting group removal, brevifoliol 13-[N-benzoyl-(2′R,3′S)-3′-phenylisoserinate] (3). This novel taxol analogue was found to be inactive in the microtubule binding assay and had little cytotoxicity against B16 melanoma cells.",

author = "Georg, \{Gunda I.\} and Cheruvallath, \{Zacharia S.\} and Velde, \{David Vander\} and Ye, \{Qing Mei\} and Mitscher, \{Lester A.\} and Himes, \{Richard H.\}",

year = "1993",

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language = "English (US)",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Semisynthesis and biological evaluation of brevifoliol 13-[N-benzoyl-(-2′R,3′S)-3′-phenylisoserinate]

AU - Georg, Gunda I.

AU - Cheruvallath, Zacharia S.

AU - Velde, David Vander

AU - Ye, Qing Mei

AU - Mitscher, Lester A.

AU - Himes, Richard H.

PY - 1993/6

Y1 - 1993/6

N2 - Coupling between brevifoliol (1) and β-lactam (2) yielded, after protecting group removal, brevifoliol 13-[N-benzoyl-(2′R,3′S)-3′-phenylisoserinate] (3). This novel taxol analogue was found to be inactive in the microtubule binding assay and had little cytotoxicity against B16 melanoma cells.

AB - Coupling between brevifoliol (1) and β-lactam (2) yielded, after protecting group removal, brevifoliol 13-[N-benzoyl-(2′R,3′S)-3′-phenylisoserinate] (3). This novel taxol analogue was found to be inactive in the microtubule binding assay and had little cytotoxicity against B16 melanoma cells.

UR - https://www.scopus.com/pages/publications/0027309193

UR - https://www.scopus.com/pages/publications/0027309193#tab=citedBy

U2 - 10.1016/S0960-894X(00)80346-7

DO - 10.1016/S0960-894X(00)80346-7

M3 - Article

AN - SCOPUS:0027309193

SN - 0960-894X

VL - 3

SP - 1349

EP - 1350

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Semisynthesis and biological evaluation of brevifoliol 13-[N-benzoyl-(-2′R,3′S)-3′-phenylisoserinate]

Abstract

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