Semiparametric maximum likelihood variance component estimation using mixture moment structure models

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Abstract

Nonnormal phenotypic distributions introduce significant problems in the estimation and selection of genetic models. Here, a semiparametric maximum likelihood approach to analyzing nonnormal phenotypes is described. In this approach, distributions are explicitly modeled together with genetic and environmental effects. Distributional parameters are introduced through mixture constraints, where the distribution of effects are discretized and freely estimated rather than assumed to be normal. Semiparametric maximum likelihood estimation can be used with a variety of genetic models, can be extended to a variety of pedigree structures, and has various advantages over other approaches to modeling nonnormal data.

Original languageEnglish (US)
Pages (from-to)360-366
Number of pages7
JournalTwin Research and Human Genetics
Volume9
Issue number3
DOIs
StatePublished - Jun 2006

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