Semen quality in fertile men in relation to psychosocial stress

Audra L. Gollenberg, Fan Liu, Charlene Brazil, Erma Z. Drobnis, David Guzick, James W. Overstreet, James B. Redmon, Amy Sparks, Christina Wang, Shanna H. Swan

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Objective: To examine the association between stressful life events and semen parameters. Design: Cross-sectional analysis in a pregnancy cohort study. Setting: Prenatal clinics in five U.S. cities. Patient(s): Fertile men (n = 744) in the Study for Future Families, a cohort study of pregnant women and their partners. Intervention(s): None. Main Outcome Measure(s): Sperm concentration, percent motile, and percent normal morphology and classification above/below World Health Organization (WHO) cutoffs for semen quality. Result(s): After adjusting for confounders, men reporting 2+ recent stressful life events had an increased risk of being classified below WHO thresholds for "normal" defined by concentration, motility, and morphology criteria compared with men reporting <2 stressful life events (odds ratio [OR] = 2.06; 95% confidence interval [CI], 1.18, 3.61; OR = 1.54; 95% CI, 1.04, 2.29; OR = 1.93; 95% CI, 1.02, 3.66 for concentration, motility and morphology, respectively). Men experiencing 2+ stressful life events had lower sperm concentration (log scale, β = -0.25; 95% CI, -0.38, -0.11) and lower percent motile sperm (β = -1.95; 95% CI, -3.98, 0.07), but percent normal morphology was less affected. Conclusion(s): These results suggest that stressful life events may be associated with decreased semen quality in fertile men. The experience of psychosocial stress may be a modifiable factor in the development of idiopathic infertility.

Original languageEnglish (US)
Pages (from-to)1104-1111
Number of pages8
JournalFertility and Sterility
Volume93
Issue number4
DOIs
StatePublished - Mar 1 2010

Fingerprint

Semen Analysis
Confidence Intervals
Spermatozoa
Odds Ratio
Cohort Studies
Semen
Infertility
Pregnant Women
Cross-Sectional Studies
Outcome Assessment (Health Care)
Pregnancy

Keywords

  • Sperm concentration
  • life events
  • psychosocial stress
  • semen quality
  • sperm morphology
  • sperm motility

Cite this

Gollenberg, A. L., Liu, F., Brazil, C., Drobnis, E. Z., Guzick, D., Overstreet, J. W., ... Swan, S. H. (2010). Semen quality in fertile men in relation to psychosocial stress. Fertility and Sterility, 93(4), 1104-1111. https://doi.org/10.1016/j.fertnstert.2008.12.018

Semen quality in fertile men in relation to psychosocial stress. / Gollenberg, Audra L.; Liu, Fan; Brazil, Charlene; Drobnis, Erma Z.; Guzick, David; Overstreet, James W.; Redmon, James B.; Sparks, Amy; Wang, Christina; Swan, Shanna H.

In: Fertility and Sterility, Vol. 93, No. 4, 01.03.2010, p. 1104-1111.

Research output: Contribution to journalArticle

Gollenberg, AL, Liu, F, Brazil, C, Drobnis, EZ, Guzick, D, Overstreet, JW, Redmon, JB, Sparks, A, Wang, C & Swan, SH 2010, 'Semen quality in fertile men in relation to psychosocial stress', Fertility and Sterility, vol. 93, no. 4, pp. 1104-1111. https://doi.org/10.1016/j.fertnstert.2008.12.018
Gollenberg AL, Liu F, Brazil C, Drobnis EZ, Guzick D, Overstreet JW et al. Semen quality in fertile men in relation to psychosocial stress. Fertility and Sterility. 2010 Mar 1;93(4):1104-1111. https://doi.org/10.1016/j.fertnstert.2008.12.018
Gollenberg, Audra L. ; Liu, Fan ; Brazil, Charlene ; Drobnis, Erma Z. ; Guzick, David ; Overstreet, James W. ; Redmon, James B. ; Sparks, Amy ; Wang, Christina ; Swan, Shanna H. / Semen quality in fertile men in relation to psychosocial stress. In: Fertility and Sterility. 2010 ; Vol. 93, No. 4. pp. 1104-1111.
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