Semen parameters in fertile US men

The Study for Future Families

Bruce B Redmon, W. Thomas, W. Ma, E. Z. Drobnis, A. Sparks, C. Wang, C. Brazil, J. W. Overstreet, F. Liu, S. H. Swan, B. S. Carter, D. J. Kelly, S. L. Stewart, T. M. Simmons, C. Treece, C. Tollner, R. S. Swerdloff, L. Lumbreras, S. Villanueva, M. Diaz-Romero & 25 others A. Victoroff, R. Sandoval, S. Bravarian, A. Leung, A. L. Nelson, C. Hobel, B. Brock, M. Hatch, M. Pfeiffer, L. Quinones, K. Polgar, A. Brembridge, C. Kwong, A. Muehlen, T. Perrier, T. Srb, Jon L Pryor, C. DeJonge, M. Swanson, T. Grider, L. Fisher, M. Maifeld, J. Whitham, A. Wolf, J. Sandlow

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Establishing reference norms for semen parameters in fertile men is important for accurate assessment, counselling and treatment of men with male factor infertility. Identifying temporal or geographic variability in semen quality also requires accurate measurement of semen parameters in well-characterized, defined populations of men. The Study for Future Families (SFF) recruited men who were partners of pregnant women attending prenatal clinics in Los Angeles CA, Minneapolis MN, Columbia MO, New York City NY and Iowa City IA. Semen samples were collected on site from 763 men (73% White, 15% Hispanic/Latino, 7% Black and 5% Asian or other ethnic group) using strict quality control and well-defined protocols. Semen volume (by weight), sperm concentration (hemacytometer) and sperm motility were measured at each centre. Sperm morphology (both WHO, 1999 strict and WHO, 1987) was determined at a central laboratory. Mean abstinence was 3.2 days. Mean (median; 5th-95th percentile) values were: semen volume, 3.9 (3.7; 1.5-6.8) mL; sperm concentration, 60 (67; 12-192) × 106/mL; total sperm count 209 (240; 32-763) × 106; % motile, 51 (52; 28-67) %; and total motile sperm count, 104 (128; 14-395) × 106 respectively. Values for sperm morphology were 11 (10; 3-20) % and 57 (59; 38-72) % normal forms for WHO (1999) (strict) and WHO (1987) criteria respectively. Black men had significantly lower semen volume, sperm concentration and total motile sperm counts than White and Hispanic/Latino men. Semen parameters were marginally higher in men who achieved pregnancy more quickly but differences were small and not statistically significant. The SFF provides robust estimates of semen parameters in fertile men living in five different geographic locations in the US. Fertile men display wide variation in all of the semen parameters traditionally used to assess fertility potential.

Original languageEnglish (US)
Pages (from-to)806-814
Number of pages9
JournalAndrology
Volume1
Issue number6
DOIs
StatePublished - Nov 1 2013

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Semen
Spermatozoa
Hispanic Americans
Sperm Count
Geographic Locations
Semen Analysis
Los Angeles
Sperm Motility
Male Infertility
Ethnic Groups
Quality Control
Fertility
Counseling
Pregnant Women
Weights and Measures
Pregnancy

Keywords

  • Sperm concentration
  • Sperm morphology
  • Sperm motility

Cite this

Redmon, B. B., Thomas, W., Ma, W., Drobnis, E. Z., Sparks, A., Wang, C., ... Sandlow, J. (2013). Semen parameters in fertile US men: The Study for Future Families. Andrology, 1(6), 806-814. https://doi.org/10.1111/j.2047-2927.2013.00125.x

Semen parameters in fertile US men : The Study for Future Families. / Redmon, Bruce B; Thomas, W.; Ma, W.; Drobnis, E. Z.; Sparks, A.; Wang, C.; Brazil, C.; Overstreet, J. W.; Liu, F.; Swan, S. H.; Carter, B. S.; Kelly, D. J.; Stewart, S. L.; Simmons, T. M.; Treece, C.; Tollner, C.; Swerdloff, R. S.; Lumbreras, L.; Villanueva, S.; Diaz-Romero, M.; Victoroff, A.; Sandoval, R.; Bravarian, S.; Leung, A.; Nelson, A. L.; Hobel, C.; Brock, B.; Hatch, M.; Pfeiffer, M.; Quinones, L.; Polgar, K.; Brembridge, A.; Kwong, C.; Muehlen, A.; Perrier, T.; Srb, T.; Pryor, Jon L; DeJonge, C.; Swanson, M.; Grider, T.; Fisher, L.; Maifeld, M.; Whitham, J.; Wolf, A.; Sandlow, J.

In: Andrology, Vol. 1, No. 6, 01.11.2013, p. 806-814.

Research output: Contribution to journalArticle

Redmon, BB, Thomas, W, Ma, W, Drobnis, EZ, Sparks, A, Wang, C, Brazil, C, Overstreet, JW, Liu, F, Swan, SH, Carter, BS, Kelly, DJ, Stewart, SL, Simmons, TM, Treece, C, Tollner, C, Swerdloff, RS, Lumbreras, L, Villanueva, S, Diaz-Romero, M, Victoroff, A, Sandoval, R, Bravarian, S, Leung, A, Nelson, AL, Hobel, C, Brock, B, Hatch, M, Pfeiffer, M, Quinones, L, Polgar, K, Brembridge, A, Kwong, C, Muehlen, A, Perrier, T, Srb, T, Pryor, JL, DeJonge, C, Swanson, M, Grider, T, Fisher, L, Maifeld, M, Whitham, J, Wolf, A & Sandlow, J 2013, 'Semen parameters in fertile US men: The Study for Future Families', Andrology, vol. 1, no. 6, pp. 806-814. https://doi.org/10.1111/j.2047-2927.2013.00125.x
Redmon, Bruce B ; Thomas, W. ; Ma, W. ; Drobnis, E. Z. ; Sparks, A. ; Wang, C. ; Brazil, C. ; Overstreet, J. W. ; Liu, F. ; Swan, S. H. ; Carter, B. S. ; Kelly, D. J. ; Stewart, S. L. ; Simmons, T. M. ; Treece, C. ; Tollner, C. ; Swerdloff, R. S. ; Lumbreras, L. ; Villanueva, S. ; Diaz-Romero, M. ; Victoroff, A. ; Sandoval, R. ; Bravarian, S. ; Leung, A. ; Nelson, A. L. ; Hobel, C. ; Brock, B. ; Hatch, M. ; Pfeiffer, M. ; Quinones, L. ; Polgar, K. ; Brembridge, A. ; Kwong, C. ; Muehlen, A. ; Perrier, T. ; Srb, T. ; Pryor, Jon L ; DeJonge, C. ; Swanson, M. ; Grider, T. ; Fisher, L. ; Maifeld, M. ; Whitham, J. ; Wolf, A. ; Sandlow, J. / Semen parameters in fertile US men : The Study for Future Families. In: Andrology. 2013 ; Vol. 1, No. 6. pp. 806-814.
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AU - Thomas, W.

AU - Ma, W.

AU - Drobnis, E. Z.

AU - Sparks, A.

AU - Wang, C.

AU - Brazil, C.

AU - Overstreet, J. W.

AU - Liu, F.

AU - Swan, S. H.

AU - Carter, B. S.

AU - Kelly, D. J.

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AU - Tollner, C.

AU - Swerdloff, R. S.

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AU - Diaz-Romero, M.

AU - Victoroff, A.

AU - Sandoval, R.

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AU - Leung, A.

AU - Nelson, A. L.

AU - Hobel, C.

AU - Brock, B.

AU - Hatch, M.

AU - Pfeiffer, M.

AU - Quinones, L.

AU - Polgar, K.

AU - Brembridge, A.

AU - Kwong, C.

AU - Muehlen, A.

AU - Perrier, T.

AU - Srb, T.

AU - Pryor, Jon L

AU - DeJonge, C.

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AU - Grider, T.

AU - Fisher, L.

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AU - Sandlow, J.

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