Semen and reproductive hormone parameters in fertile men with and without varicocele

Bruce B Redmon, Erma Z. Drobnis, Amy Sparks, Christina Wang, Shanna H. Swan

Research output: Contribution to journalArticle

Abstract

Although varicoceles are a widely accepted identifiable male factor in infertile couples, the benefit of varicocele repair in improving pregnancy and live birth rates remains uncertain. The Study for Future Families obtained semen and reproductive hormone samples from US men whose partners were currently pregnant. In our analysis cohort of 709 men, a varicocele was detected by clinical examination in 56 (8%) of men. Men with varicocele had smaller left testis, and lower total and total motile sperm counts than men without varicocele. Gonadotropin levels were higher as well in men with varicocele. Interestingly, testosterone levels were also slightly higher in men with varicocele. Despite these differences, there was no difference between the groups in the time to achieve the study pregnancy or percentage of men with a previous pregnancy. We conclude that even in fertile men, varicoceles are associated with some degree of testicular hypofunction. This would support current recommendations to consider varicocele repair in male partners in infertile couples who demonstrate both a varicocele and abnormal semen parameters and after evaluation for treatable female factors.

Original languageEnglish (US)
Article numbere13407
JournalAndrologia
DOIs
StatePublished - Jan 1 2019

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Varicocele
Semen
Hormones
Pregnancy
Sperm Count
Pregnancy Rate
Gonadotropins
Testosterone
Testis
Cohort Studies

Keywords

  • fertile
  • male hormones
  • men
  • semen
  • varicocele

PubMed: MeSH publication types

  • Journal Article

Cite this

Semen and reproductive hormone parameters in fertile men with and without varicocele. / Redmon, Bruce B; Drobnis, Erma Z.; Sparks, Amy; Wang, Christina; Swan, Shanna H.

In: Andrologia, 01.01.2019.

Research output: Contribution to journalArticle

Redmon, Bruce B ; Drobnis, Erma Z. ; Sparks, Amy ; Wang, Christina ; Swan, Shanna H. / Semen and reproductive hormone parameters in fertile men with and without varicocele. In: Andrologia. 2019.
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