Semaphorin II can function as a selective inhibitor of specific synaptic arborizations

David J Matthes, Helen Sink, Alex L. Kolodkin, Corey S. Goodman

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

Previous studies showed that grasshopper semaphorin I, a transmembrane semaphorin, functions in vivo to steer a pair of growth cones, prevent defasciculation, and inhibit branching; and that chick collapsin, a secreted semaphorin, can function in vitro to cause growth cone collapse. Semaphorin 11, a secreted semaphorin in Drosophila, is transiently expressed by a single large muscle during motoneuron outgrowth and synapse formation. To test the in vivo function of semaphorin 11, we created transgenic Drosophila that generate ectopic semaphorin 11 expression by muscles that normally do not express it. The results show that semaphorin II can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors.

Original languageEnglish (US)
Pages (from-to)631-639
Number of pages9
JournalCell
Volume81
Issue number4
DOIs
StatePublished - May 19 1995

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Semaphorins
Growth Cones
Drosophila
Muscle
Cones
Semaphorin-3A
Muscles
Grasshoppers
Presynaptic Terminals
Motor Neurons
Synapses

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Semaphorin II can function as a selective inhibitor of specific synaptic arborizations. / Matthes, David J; Sink, Helen; Kolodkin, Alex L.; Goodman, Corey S.

In: Cell, Vol. 81, No. 4, 19.05.1995, p. 631-639.

Research output: Contribution to journalArticle

Matthes, David J ; Sink, Helen ; Kolodkin, Alex L. ; Goodman, Corey S. / Semaphorin II can function as a selective inhibitor of specific synaptic arborizations. In: Cell. 1995 ; Vol. 81, No. 4. pp. 631-639.
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