Self-reported effectiveness and physician consultation rate in users of over-the-counter histamine-2 receptor antagonists

Michael J Shaw, A. Mark Fendrick, Robert L. Kane, Susan A. Adlis, Nicholas J. Talley

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


OBJECTIVE: Decreased physician visits for dyspepsia were predicted with the histamine-2 receptor antagonists (H2RA) release to over-the-counter (OTC) status. The aim of this study was to examine the presentation frequency for dyspeptic complaints before and after the OTC release of the H2RA and the self-reported effectiveness of OTC H2RA. METHODS: Two cross-sectional surveys were used in a community sample. The patients comprised a random age- and sex-stratified sample of 1600 ambulatory adults in 1993 and 1800 in 1997. Self-report, valid mail surveys gathered information on healthcare seeking and gastrointestinal symptoms in 1993 and 1997 and antisecretory use in 1997. RESULTS: Presentation frequency for dyspepsia was 22% in 1993 versus 23.5% in 1997. Only 16% of chronic users of the OTC H2RA obtained complete relief of symptomatic episodes. Use of an OTC H2RA was highly associated with presentation to a physician in the past year. CONCLUSIONS: OTC H2RA infrequently provided the complete relief desired by patients. Presentation frequency to physicians for dyspeptic complaints did not change with availability of H2RA OTC.

Original languageEnglish (US)
Article number3602
Pages (from-to)673-676
Number of pages4
JournalAmerican Journal of Gastroenterology
Issue number3
StatePublished - 2001

Bibliographical note

Funding Information:
This study was supported in part by an unrestricted grant from AstraZeneca, Wayne, Pennsylvania.

Copyright 2017 Elsevier B.V., All rights reserved.

Fingerprint Dive into the research topics of 'Self-reported effectiveness and physician consultation rate in users of over-the-counter histamine-2 receptor antagonists'. Together they form a unique fingerprint.

Cite this