Self-regulating model for control of replication origin firing in budding yeast.

Laura Díaz-Martínez, Duncan J. Clarke

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A major research area concentrates on understanding the regulation of replication origin firing. It is now appreciated that checkpoint signaling participates in this controlled process and that defects in such signaling systems affect genome integrity. Inhibition of replication origin firing is most obviously apparent under conditions of replication stress, but origin firing must also be regulated on a minute-by-minute basis as cells progress normally through an unabated S-phase. Here we summarize a straightforward model to account for how origin firing could be controlled by a self-regulating system.

Original languageEnglish (US)
Pages (from-to)575-577
Number of pages3
JournalCell cycle (Georgetown, Tex.)
Issue number6
StatePublished - Jan 1 2003


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