Self-immolative aryl phthalate esters

Kaitlyn M. Mahoney; Pratik P. Goswami; Arthur H. Winter

doi:10.1021/jo301698v

Self-immolative aryl phthalate esters

Kaitlyn M. Mahoney, Pratik P. Goswami, Arthur H. Winter

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications.

Original language	English (US)
Pages (from-to)	702-705
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	78
Issue number	2
DOIs	https://doi.org/10.1021/jo301698v
State	Published - Jan 18 2013
Externally published	Yes

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10.1021/jo301698v

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title = "Self-immolative aryl phthalate esters",

abstract = "We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications.",

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AU - Winter, Arthur H.

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AB - We report that aryl phthalate esters are robust self-immolative linkers. This linker is easy to conjugate and releases output phenols upon cleaving a fluoride-sensitive mask to yield a benign phthalic acid byproduct, making these linkers potentially useful as fluoride sensors and promising for use in biological and materials applications.

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Self-immolative aryl phthalate esters

Abstract

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