The purpose of the present study was to compare the emotional reactions of depressed and nondepressed individuals to experiences of romantic rejection versus acceptance. We tested our hypotheses in a sample of 28 depressed and 43 nondepressed undergraduate students. In support of self-consistency theories, the results showed that depressed individuals reported significantly greater negative mood in the romantic acceptance versus rejection condition, while there was no significant difference across the two conditions in the self-reported mood of nondepressed individuals. Further, symptoms of anxiety mediated the interactive effects of depression status and rejection status on mood. Our findings demonstrate how the responses of depressed individuals to interpersonal feedback contribute to their affective disturbance.