Self-assembly and applications of biomimetic and bioactive peptide-amphiphiles

Efrosini Kokkoli, Anastasia Mardilovich, Alison Wedekind, Emilie L. Rexeisen, Ashish Garg, Jennifer A. Craig

Research output: Contribution to journalReview article

147 Scopus citations

Abstract

Peptide-amphiphiles are amphiphilic structures with a hydrophilic peptide headgroup that incorporates a bioactive sequence and has the potential to form distinct structures, and a hydrophobic tail that serves to align the headgroup, drive self-assembly, and induce secondary and tertiary conformations. In this paper we review the different self-assembled structures of peptide-amphiphiles that range from micelles and nanofibers, to patterned membranes. We also describe several examples where peptide-amphiphiles have found applications as soft bioactive materials for model studies of bioadhesion and characterization of different cellular phenomena, as well as scaffolds for tissue engineering, regenerative medicine, and targeted drug delivery.

Original languageEnglish (US)
Pages (from-to)1015-1024
Number of pages10
JournalSoft Matter
Volume2
Issue number12
DOIs
StatePublished - Nov 20 2006

Fingerprint Dive into the research topics of 'Self-assembly and applications of biomimetic and bioactive peptide-amphiphiles'. Together they form a unique fingerprint.

  • Cite this

    Kokkoli, E., Mardilovich, A., Wedekind, A., Rexeisen, E. L., Garg, A., & Craig, J. A. (2006). Self-assembly and applications of biomimetic and bioactive peptide-amphiphiles. Soft Matter, 2(12), 1015-1024. https://doi.org/10.1039/b608929a