Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers

M. E. Davis, S. H. Pun, N. C. Bellocq, T. M. Reineke, S. R. Popielarski, S. Mishra, J. D. Heidel

Research output: Contribution to journalReview article

126 Scopus citations

Abstract

Non-viral (synthetic) nucleic acid delivery systems have the potential to provide for the practical application of nucleic acid-based therapeutics. We have designed and prepared a tunable, non-viral nucleic acid delivery system that self-assembles with nucleic acids and centers around a new class of polymeric materials; namely, linear, water-soluble cyclodextrin-containing polymers. The relationships between polymer structure and gene delivery are illustrated, and the roles of the cyclodextrin moieties for minimizing toxicity and forming inclusion complexes in the self-assembly processes are highlighted. This vehicle is the first example of a polymer-based gene delivery system formed entirely by self-assembly.

Original languageEnglish (US)
Pages (from-to)179-197
Number of pages19
JournalCurrent Medicinal Chemistry
Volume11
Issue number2
DOIs
StatePublished - Feb 5 2004

Keywords

  • Cyclodextrin-polymers
  • Gene delivery
  • Non-viral delivery
  • Nucleic acid delivery
  • Self-assembly
  • Supramolecular structures

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