Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo

Matthew Black; Amanda Trent; Yulia Kostenko; Joseph Saeyong Lee; Colleen Olive; Matthew Tirrell

doi:10.1002/adma.201200209

Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo

Matthew Black
, Amanda Trent
, Yulia Kostenko
, Joseph Saeyong Lee
, Colleen Olive
, Matthew Tirrell

Research output: Contribution to journal › Article › peer-review

233 Scopus citations

Abstract

A model cytotoxic T-cell epitope is linked to a synthetic lipid tail, forming a peptide amphiphile that self-assembles into cylindrical micelles. The micelles are capable of inducing a cytotoxic T-cell response in mice that slows the growth of tumors expressing the tumor antigen.

Original language	English (US)
Pages (from-to)	3845-3849
Number of pages	5
Journal	Advanced Materials
Volume	24
Issue number	28
DOIs	https://doi.org/10.1002/adma.201200209
State	Published - Jul 24 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

biomolecular materials
immunotherapy
micelles
nanoparticles
peptide amphiphiles

Publisher link

10.1002/adma.201200209

Find It

Find It at U of M Libraries

Cite this

@article{568ad2cbdb3d46ea98cc09d56369d785,

title = "Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo",

abstract = "A model cytotoxic T-cell epitope is linked to a synthetic lipid tail, forming a peptide amphiphile that self-assembles into cylindrical micelles. The micelles are capable of inducing a cytotoxic T-cell response in mice that slows the growth of tumors expressing the tumor antigen.",

keywords = "biomolecular materials, immunotherapy, micelles, nanoparticles, peptide amphiphiles",

author = "Matthew Black and Amanda Trent and Yulia Kostenko and Lee, \{Joseph Saeyong\} and Colleen Olive and Matthew Tirrell",

year = "2012",

month = jul,

day = "24",

doi = "10.1002/adma.201200209",

language = "English (US)",

volume = "24",

pages = "3845--3849",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

number = "28",

}

TY - JOUR

T1 - Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo

AU - Black, Matthew

AU - Trent, Amanda

AU - Kostenko, Yulia

AU - Lee, Joseph Saeyong

AU - Olive, Colleen

AU - Tirrell, Matthew

PY - 2012/7/24

Y1 - 2012/7/24

N2 - A model cytotoxic T-cell epitope is linked to a synthetic lipid tail, forming a peptide amphiphile that self-assembles into cylindrical micelles. The micelles are capable of inducing a cytotoxic T-cell response in mice that slows the growth of tumors expressing the tumor antigen.

AB - A model cytotoxic T-cell epitope is linked to a synthetic lipid tail, forming a peptide amphiphile that self-assembles into cylindrical micelles. The micelles are capable of inducing a cytotoxic T-cell response in mice that slows the growth of tumors expressing the tumor antigen.

KW - biomolecular materials

KW - immunotherapy

KW - micelles

KW - nanoparticles

KW - peptide amphiphiles

UR - https://www.scopus.com/pages/publications/84864133449

UR - https://www.scopus.com/pages/publications/84864133449#tab=citedBy

U2 - 10.1002/adma.201200209

DO - 10.1002/adma.201200209

M3 - Article

C2 - 22550019

AN - SCOPUS:84864133449

SN - 0935-9648

VL - 24

SP - 3845

EP - 3849

JO - Advanced Materials

JF - Advanced Materials

IS - 28

ER -

Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo

Abstract

UN SDGs

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this