Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo

Matthew Black, Amanda Trent, Yulia Kostenko, Joseph Saeyong Lee, Colleen Olive, Matthew Tirrell

Research output: Contribution to journalArticlepeer-review

210 Scopus citations

Abstract

A model cytotoxic T-cell epitope is linked to a synthetic lipid tail, forming a peptide amphiphile that self-assembles into cylindrical micelles. The micelles are capable of inducing a cytotoxic T-cell response in mice that slows the growth of tumors expressing the tumor antigen.

Original languageEnglish (US)
Pages (from-to)3845-3849
Number of pages5
JournalAdvanced Materials
Volume24
Issue number28
DOIs
StatePublished - Jul 24 2012
Externally publishedYes

Keywords

  • biomolecular materials
  • immunotherapy
  • micelles
  • nanoparticles
  • peptide amphiphiles

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