Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo

Matthew Black; Amanda Trent; Yulia Kostenko; Joseph Saeyong Lee; Colleen Olive; Matthew Tirrell

doi:10.1002/adma.201200209

Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo

Matthew Black, Amanda Trent, Yulia Kostenko, Joseph Saeyong Lee, Colleen Olive, Matthew Tirrell

Research output: Contribution to journal › Article › peer-review

225 Scopus citations

Abstract

A model cytotoxic T-cell epitope is linked to a synthetic lipid tail, forming a peptide amphiphile that self-assembles into cylindrical micelles. The micelles are capable of inducing a cytotoxic T-cell response in mice that slows the growth of tumors expressing the tumor antigen.

Original language	English (US)
Pages (from-to)	3845-3849
Number of pages	5
Journal	Advanced Materials
Volume	24
Issue number	28
DOIs	https://doi.org/10.1002/adma.201200209
State	Published - Jul 24 2012
Externally published	Yes

Keywords

biomolecular materials
immunotherapy
micelles
nanoparticles
peptide amphiphiles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adma.201200209

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title = "Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo",

abstract = "A model cytotoxic T-cell epitope is linked to a synthetic lipid tail, forming a peptide amphiphile that self-assembles into cylindrical micelles. The micelles are capable of inducing a cytotoxic T-cell response in mice that slows the growth of tumors expressing the tumor antigen.",

keywords = "biomolecular materials, immunotherapy, micelles, nanoparticles, peptide amphiphiles",

author = "Matthew Black and Amanda Trent and Yulia Kostenko and Lee, {Joseph Saeyong} and Colleen Olive and Matthew Tirrell",

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AU - Black, Matthew

AU - Trent, Amanda

AU - Kostenko, Yulia

AU - Lee, Joseph Saeyong

AU - Olive, Colleen

AU - Tirrell, Matthew

PY - 2012/7/24

Y1 - 2012/7/24

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AB - A model cytotoxic T-cell epitope is linked to a synthetic lipid tail, forming a peptide amphiphile that self-assembles into cylindrical micelles. The micelles are capable of inducing a cytotoxic T-cell response in mice that slows the growth of tumors expressing the tumor antigen.

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KW - immunotherapy

KW - micelles

KW - nanoparticles

KW - peptide amphiphiles

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Self-assembled peptide amphiphile micelles containing a cytotoxic T-cell epitope promote a protective immune response in vivo

Abstract

Keywords

UN SDGs

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