Selenium, vitamin E and the response to swimming stress in the rat

P. S. Brady, L. J. Brady, D. E. Ullrey

Research output: Contribution to journalArticlepeer-review

135 Scopus citations


Experiments were conducted to determine the effects of exercise on rat glutathione peroxidase system enzymes and lipid peroxidation among animals supplemented and unsupplemented with selenium (Se) and vitamin E (E). Liver, muscle and blood were taken before, immediately after and 24 hours after exercising to exhaustion by swimming. No effect of exercise was found on muscle or liver enzymes, although exercise resulted in depressed glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G6PD) activities in erythrocytes immediately after exercise. Dietary Se supplementation did result in increased hepatic, muscle and erythrocyte glutathione peroxidase activity, and decreased hepatic GR, G6PD and 'malic enzyme' activities. Thiobarbituric acid reactive substances, an indicator of lipid peroxidation, increased in liver and muscle subsequent to exercise. This increase was reduced in liver, but not eliminated, by dietary E supplementation. The increase was not affected by dietary E in muscle, nor by dietary Se in either tissue.

Original languageEnglish (US)
Pages (from-to)1103-1109
Number of pages7
JournalJournal of Nutrition
Issue number6
StatePublished - 1979
Externally publishedYes


Dive into the research topics of 'Selenium, vitamin E and the response to swimming stress in the rat'. Together they form a unique fingerprint.

Cite this