TY - JOUR
T1 - Selenium, vitamin E and the response to swimming stress in the rat
AU - Brady, P. S.
AU - Brady, L. J.
AU - Ullrey, D. E.
PY - 1979
Y1 - 1979
N2 - Experiments were conducted to determine the effects of exercise on rat glutathione peroxidase system enzymes and lipid peroxidation among animals supplemented and unsupplemented with selenium (Se) and vitamin E (E). Liver, muscle and blood were taken before, immediately after and 24 hours after exercising to exhaustion by swimming. No effect of exercise was found on muscle or liver enzymes, although exercise resulted in depressed glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G6PD) activities in erythrocytes immediately after exercise. Dietary Se supplementation did result in increased hepatic, muscle and erythrocyte glutathione peroxidase activity, and decreased hepatic GR, G6PD and 'malic enzyme' activities. Thiobarbituric acid reactive substances, an indicator of lipid peroxidation, increased in liver and muscle subsequent to exercise. This increase was reduced in liver, but not eliminated, by dietary E supplementation. The increase was not affected by dietary E in muscle, nor by dietary Se in either tissue.
AB - Experiments were conducted to determine the effects of exercise on rat glutathione peroxidase system enzymes and lipid peroxidation among animals supplemented and unsupplemented with selenium (Se) and vitamin E (E). Liver, muscle and blood were taken before, immediately after and 24 hours after exercising to exhaustion by swimming. No effect of exercise was found on muscle or liver enzymes, although exercise resulted in depressed glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G6PD) activities in erythrocytes immediately after exercise. Dietary Se supplementation did result in increased hepatic, muscle and erythrocyte glutathione peroxidase activity, and decreased hepatic GR, G6PD and 'malic enzyme' activities. Thiobarbituric acid reactive substances, an indicator of lipid peroxidation, increased in liver and muscle subsequent to exercise. This increase was reduced in liver, but not eliminated, by dietary E supplementation. The increase was not affected by dietary E in muscle, nor by dietary Se in either tissue.
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U2 - 10.1093/jn/109.6.1103
DO - 10.1093/jn/109.6.1103
M3 - Article
C2 - 448449
AN - SCOPUS:0018776943
SN - 0022-3166
VL - 109
SP - 1103
EP - 1109
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 6
ER -