Selenium and vitamin E deficiencies do not enhance lung inflammation from cigarette smoke in the hamster

D. E. Niewoehner, F. J. Peterson, J. R. Hoidal

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The early lung inflammatory response to cigarette smoke may be oxidant-mediated. We fed Syrian hamsters a diet deficient in selenium and vitamin E to determine whether impairment of the lung's antioxidant defenses might worsen inflammation induced by cigarette smoke. After 8 wk, cigarette-smoke-exposed animals had characteristic inflammatory lesions in the distal airways. Increased numbers of phagocytes, predominantly macrophages, were recovered by lavage and these cells exhibited enhanced oxidative metabolism. Animals fed the deficient diet had profound depletions of selenium and vitamin E, but no alterations in the histologic appearance of smoke-induced inflammatory lesions, in the numbers of phagocytes recruited, or in the oxidative metabolism of these phagocytes. These results suggest that selenium and vitamin E are unimportant in protecting against cigarette-smoke-induced lung injury.

Original languageEnglish (US)
Pages (from-to)227-230
Number of pages4
JournalAmerican Review of Respiratory Disease
Volume127
Issue number2
StatePublished - Jan 1 1983

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