Selective syntheses of 6-substituted pyrimidine nucleosides and their interactions with uridine phosphorylase.

K. Felczak; I. Samulewicz; A. K. Drabikowska; T. Kulikowski; D. Shugar

Selective syntheses of 6-substituted pyrimidine nucleosides and their interactions with uridine phosphorylase.

K. Felczak, I. Samulewicz, A. K. Drabikowska, T. Kulikowski, D. Shugar

Research output: Contribution to journal › Article › peer-review

Abstract

Several 6-substituted pyrimidine nucleosides have been prepared by condensation of an N(3)-benzyl or C(4)-methylthio pyrimidine with the appropriately blocked sugar, followed by the use of mild conditions at room temperature for removal of blocking groups. The substrate properties of these nucleosides, which are in the fixed syn conformation, have been examined in the uridine phosphorylase system.

Original language	English (US)
Pages (from-to)	65-68
Number of pages	4
Journal	Nucleic acids symposium series
Issue number	18
State	Published - 1987
Externally published	Yes

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abstract = "Several 6-substituted pyrimidine nucleosides have been prepared by condensation of an N(3)-benzyl or C(4)-methylthio pyrimidine with the appropriately blocked sugar, followed by the use of mild conditions at room temperature for removal of blocking groups. The substrate properties of these nucleosides, which are in the fixed syn conformation, have been examined in the uridine phosphorylase system.",

author = "K. Felczak and I. Samulewicz and Drabikowska, {A. K.} and T. Kulikowski and D. Shugar",

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AU - Felczak, K.

AU - Samulewicz, I.

AU - Drabikowska, A. K.

AU - Kulikowski, T.

AU - Shugar, D.

PY - 1987

Y1 - 1987

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AB - Several 6-substituted pyrimidine nucleosides have been prepared by condensation of an N(3)-benzyl or C(4)-methylthio pyrimidine with the appropriately blocked sugar, followed by the use of mild conditions at room temperature for removal of blocking groups. The substrate properties of these nucleosides, which are in the fixed syn conformation, have been examined in the uridine phosphorylase system.

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Selective syntheses of 6-substituted pyrimidine nucleosides and their interactions with uridine phosphorylase.

Abstract

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