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Selective N-Terminal BET Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement**
Huarui Cui
, Anand Divakaran
, Anil K. Pandey
, Jorden A. Johnson
, Huda Zahid
, Zachariah J. Hoell
, Mikael O. Ellingson
,
Ke Shi
,
Hideki Aihara
,
Daniel A. Harki
,
William C.K. Pomerantz
University of Minnesota Twin Cities
Chemistry (Twin Cities)
Institute for Molecular Virology
Genetics Mechanisms of Cancer
Cellular Mechanisms of Cancer
Research output
:
Contribution to journal
›
Article
›
peer-review
39
Scopus citations
Overview
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Dive into the research topics of 'Selective N-Terminal BET Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement**'. Together they form a unique fingerprint.
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Keyphrases
Binding Site
9%
Biological Function
9%
BRD2
9%
Bromodomain
100%
Bromodomain Inhibitors
100%
Bromodomain-containing Protein 4 (BRD4)
54%
Chemical Probes
9%
Competitive Inhibition Assay
9%
D1 Inhibition
9%
Drug Target
9%
Family Protein
9%
Gene Regulation
9%
Ill-defined
9%
Lysine
9%
MM.1S
9%
Nonconserved Residues
100%
Pan-inhibitor
9%
Structured Water
100%
Water Displacement
100%
X-ray Crystallography
9%
Biochemistry, Genetics and Molecular Biology
Binding Site
8%
Biological Functions
8%
BRD2
8%
BRD4
50%
Bromodomain
100%
Competitive Inhibition
8%
Enhancer Region
8%
Gene Control
8%
Lysine
8%
Myc
8%
N-Terminus
100%
Protein Family
8%
Upregulation
8%
X-Ray Crystallography
8%