Selective impairments in implicit learning in Parkinson's disease

R. D. Seidler, P. Tuite, J. Ashe

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The basal ganglia are thought to participate in implicit sequence learning. However, the exact nature of this role has been difficult to determine in light of the conflicting evidence on implicit learning in subjects with Parkinson's disease (PD). We examined the performance of PD subjects using a modified form of the serial reaction time task, which ensured that learning remained implicit. Subjects with predominantly right-sided symptoms were trained on a 12-element sequence using the right hand. Although there was no evidence of sequence learning on the basis of response time savings, the subjects showed knowledge of the sequence when performance was assessed in terms of the number of errors made. This effect transferred to the left (untrained) hand as well. Thus, these data demonstrate that PD patients are not impaired at implicitly learning sequential order, but rather at the translation of sequence knowledge into rapid motor performance. Furthermore, the results suggest that the basal ganglia are not essential for implicit sequence learning in PD.

Original languageEnglish (US)
Pages (from-to)104-110
Number of pages7
JournalBrain Research
Volume1137
Issue number1
DOIs
StatePublished - Mar 16 2007

Bibliographical note

Funding Information:
Supported by NIH NS40106.

Keywords

  • Implicit
  • Parkinson's disease
  • Sequence learning
  • Serial reaction time

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