Selective generation of quaternary all-carbon-centres through Heck-cyclisations: Synthesis of mesembrane

Johannes Klein; Kimberly Geoghegan; Nicolas Méral; Paul Evans

doi:10.1039/b923175g

Selective generation of quaternary all-carbon-centres through Heck-cyclisations: Synthesis of mesembrane

Johannes Klein
, Kimberly Geoghegan
, Nicolas Méral
, Paul Evans

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Described is an observation that the intramolecular Heck reaction of a trisubstituted alkene proceeds with high regioselectivity and leads to the preferential formation of a quaternary all-carbon-centre. This observation was subsequently applied in a short synthesis of (±)-mesembrane.

Original language	English (US)
Pages (from-to)	937-939
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	6
DOIs	https://doi.org/10.1039/b923175g
State	Published - Feb 5 2010

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title = "Selective generation of quaternary all-carbon-centres through Heck-cyclisations: Synthesis of mesembrane",

abstract = "Described is an observation that the intramolecular Heck reaction of a trisubstituted alkene proceeds with high regioselectivity and leads to the preferential formation of a quaternary all-carbon-centre. This observation was subsequently applied in a short synthesis of (±)-mesembrane.",

author = "Johannes Klein and Kimberly Geoghegan and Nicolas M{\'e}ral and Paul Evans",

year = "2010",

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language = "English (US)",

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publisher = "Royal Society of Chemistry",

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T1 - Selective generation of quaternary all-carbon-centres through Heck-cyclisations

T2 - Synthesis of mesembrane

AU - Klein, Johannes

AU - Geoghegan, Kimberly

AU - Méral, Nicolas

AU - Evans, Paul

PY - 2010/2/5

Y1 - 2010/2/5

N2 - Described is an observation that the intramolecular Heck reaction of a trisubstituted alkene proceeds with high regioselectivity and leads to the preferential formation of a quaternary all-carbon-centre. This observation was subsequently applied in a short synthesis of (±)-mesembrane.

AB - Described is an observation that the intramolecular Heck reaction of a trisubstituted alkene proceeds with high regioselectivity and leads to the preferential formation of a quaternary all-carbon-centre. This observation was subsequently applied in a short synthesis of (±)-mesembrane.

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UR - https://www.scopus.com/pages/publications/75649105729#tab=citedBy

U2 - 10.1039/b923175g

DO - 10.1039/b923175g

M3 - Article

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AN - SCOPUS:75649105729

SN - 1359-7345

VL - 46

SP - 937

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JO - Chemical Communications

JF - Chemical Communications

IS - 6

ER -

Selective generation of quaternary all-carbon-centres through Heck-cyclisations: Synthesis of mesembrane

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