Selective generation of quaternary all-carbon-centres through Heck-cyclisations: Synthesis of mesembrane

Johannes Klein, Kimberly Geoghegan, Nicolas Méral, Paul Evans

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Described is an observation that the intramolecular Heck reaction of a trisubstituted alkene proceeds with high regioselectivity and leads to the preferential formation of a quaternary all-carbon-centre. This observation was subsequently applied in a short synthesis of (±)-mesembrane.

Original languageEnglish (US)
Pages (from-to)937-939
Number of pages3
JournalChemical Communications
Volume46
Issue number6
DOIs
StatePublished - Feb 5 2010

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