Selective Csp2-Csp bond cleavage: The nitrogenation of alkynes to amides

Chong Qin, Peng Feng, Yang Ou, Tao Shen, Teng Wang, Ning Jiao

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Breakthrough: A novel catalyzed direct highly selective C sp 2-C sp bond functionalization of alkynes to amides has been developed. Nitrogenation is achieved by the highly selective C sp 2-Csp bond cleavage of aryl-substituted alkynes. The oxidant-free and mild conditions and wide substrate scope make this method very practical.

Original languageEnglish (US)
Pages (from-to)7850-7854
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number30
DOIs
StatePublished - Jul 22 2013

Keywords

  • C-C bond cleavage
  • alkynes
  • amides
  • gold
  • rearrangement

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