Bromination of alipathic hydrocarbons with NaOH/CBr4 under phase-transfer conditions selectively gives the tertiary bromide. In the absence of a tertiary C-H bond in the molecule, a secondary bond will be activated (see reaction equation). This conceptionally new system for alipathic C-H activation very likely relies on the initiation of single-electron transfer followed by a radical substitution with unusually high regioselectivity.
|Original language||English (US)|
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Aug 3 1998|
- C-H activation
- Phase-transfer catalysis
- Single-electron transfer