Selective C-2 and C-4 deacylation and acylation of taxol: The first synthesis of a C-4 substituted taxol analogue

Gunda I. Georg, Syed M. Ali, Thomas C. Boge, Apurba Datta, Lise Falborg, Richard H. Himes

Research output: Contribution to journalArticlepeer-review

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Abstract

Hydrolytic procedures for selective 2-debenzoylation and 2,4-dideacylation of 2′-O-tert-butyldimethylsilyl-7-O-(triethylsilyl)taxol are reported. The first synthesis and biological evaluation of a 4-substituted analogue, 4-deacetyl-4-isobutanoyltaxol, is presented. The chemistry described in this letter is suitable for the facile synthesis of taxol congeners modified at C-2 and/or C-4.

Original languageEnglish (US)
Pages (from-to)8931-8934
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number48
DOIs
StatePublished - Nov 28 1994

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