TY - JOUR
T1 - Selection of self-reactive T cells in the thymus
AU - Stritesky, Gretta L.
AU - Jameson, Stephen C.
AU - Hogquist, Kristin A.
PY - 2012/4
Y1 - 2012/4
N2 - On the whole, the healthy adaptive immune system is responsive to foreign antigens and tolerant to self. However, many individual lymphocytes have, and even require, substantial self-reactivity for their particular functions in immunity. In this review, we discuss several populations of lymphocytes that are thought to experience agonist stimulation through the T cell receptor during selection: nTreg cells, iNKT cells, nIELs, and nTh17s. We discuss the nature of this self-reactivity, how it compares with conventional T cells, and why it is important for overall immune health. We also outline molecular pathways unique to each lineage and consider possible commonalities to their development and survival.
AB - On the whole, the healthy adaptive immune system is responsive to foreign antigens and tolerant to self. However, many individual lymphocytes have, and even require, substantial self-reactivity for their particular functions in immunity. In this review, we discuss several populations of lymphocytes that are thought to experience agonist stimulation through the T cell receptor during selection: nTreg cells, iNKT cells, nIELs, and nTh17s. We discuss the nature of this self-reactivity, how it compares with conventional T cells, and why it is important for overall immune health. We also outline molecular pathways unique to each lineage and consider possible commonalities to their development and survival.
KW - Intraepithelial lymphocytes
KW - Invariant natural killer T cell
KW - Natural Th17
KW - Regulatory T cell
KW - Thymic selection
KW - Tolerance
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U2 - 10.1146/annurev-immunol-020711-075035
DO - 10.1146/annurev-immunol-020711-075035
M3 - Review article
C2 - 22149933
AN - SCOPUS:84859388345
SN - 0732-0582
VL - 30
SP - 95
EP - 114
JO - Annual Review of Immunology
JF - Annual Review of Immunology
ER -