Selection for resistance to phallolysin, a cytolytic toxin from the death-cap mushroom (Amanita phalloides)

W. T. Shier; D. J. DuBourdieu; H. Kawaguchi

doi:10.1016/0041-0101(83)90103-4

Selection for resistance to phallolysin, a cytolytic toxin from the death-cap mushroom (Amanita phalloides)

W. T. Shier
, D. J. DuBourdieu
, H. Kawaguchi

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

W. T. Shier, D. J. DuBourdieu and H. Kawaguchi. Selection for resistance to phallolysin, a cytolytic toxin from the death-cap mushroom (Amanita phalloides), Toxicon 21, 447 - 450, 1983. - Phallolysin-resistant variants are readily selected from unmutagenized populations of mouse fibroblasts. They exhibit partial cross-resistance to wheat germ agglutinin, a lectin with a saccharide specificity similar to phallolysin. These results are consistent with phallolysin acting by binding to cell surface glycoprotein receptors rather than by interacting directly with lipid components of the membrane.

Original language	English (US)
Pages (from-to)	445-448
Number of pages	4
Journal	Toxicon
Volume	21
Issue number	3
DOIs	https://doi.org/10.1016/0041-0101(83)90103-4
State	Published - 1983

Bibliographical note

Funding Information:
Acknowledgements -These studies were supported by NSF grant PCM 80-11784, and by a fellowship from the Japan Educational Fund (to H .K.) . We gratefully acknowledge the gift of purified phallolysin from Professor RurH SEEGER, without which this work would not have been possible, and valuable discussions with Dr . J . P . DuRKw. Some initial studies in this work were carried out at the Salk Institute, San Diego, CA, U .S .A.

Publisher link

10.1016/0041-0101(83)90103-4

Find It

Find It at U of M Libraries

Cite this

@article{1c6c91499d324e7282fdffffb4eff2e1,

title = "Selection for resistance to phallolysin, a cytolytic toxin from the death-cap mushroom (Amanita phalloides)",

abstract = "W. T. Shier, D. J. DuBourdieu and H. Kawaguchi. Selection for resistance to phallolysin, a cytolytic toxin from the death-cap mushroom (Amanita phalloides), Toxicon 21, 447 - 450, 1983. - Phallolysin-resistant variants are readily selected from unmutagenized populations of mouse fibroblasts. They exhibit partial cross-resistance to wheat germ agglutinin, a lectin with a saccharide specificity similar to phallolysin. These results are consistent with phallolysin acting by binding to cell surface glycoprotein receptors rather than by interacting directly with lipid components of the membrane.",

author = "Shier, \{W. T.\} and DuBourdieu, \{D. J.\} and H. Kawaguchi",

note = "Funding Information: Acknowledgements -These studies were supported by NSF grant PCM 80-11784, and by a fellowship from the Japan Educational Fund (to H .K.) . We gratefully acknowledge the gift of purified phallolysin from Professor RurH SEEGER, without which this work would not have been possible, and valuable discussions with Dr . J . P . DuRKw. Some initial studies in this work were carried out at the Salk Institute, San Diego, CA, U .S .A.",

year = "1983",

doi = "10.1016/0041-0101(83)90103-4",

language = "English (US)",

volume = "21",

pages = "445--448",

journal = "Toxicon",

issn = "0041-0101",

publisher = "Elsevier Ltd",

number = "3",

}

TY - JOUR

T1 - Selection for resistance to phallolysin, a cytolytic toxin from the death-cap mushroom (Amanita phalloides)

AU - Shier, W. T.

AU - DuBourdieu, D. J.

AU - Kawaguchi, H.

N1 - Funding Information: Acknowledgements -These studies were supported by NSF grant PCM 80-11784, and by a fellowship from the Japan Educational Fund (to H .K.) . We gratefully acknowledge the gift of purified phallolysin from Professor RurH SEEGER, without which this work would not have been possible, and valuable discussions with Dr . J . P . DuRKw. Some initial studies in this work were carried out at the Salk Institute, San Diego, CA, U .S .A.

PY - 1983

Y1 - 1983

N2 - W. T. Shier, D. J. DuBourdieu and H. Kawaguchi. Selection for resistance to phallolysin, a cytolytic toxin from the death-cap mushroom (Amanita phalloides), Toxicon 21, 447 - 450, 1983. - Phallolysin-resistant variants are readily selected from unmutagenized populations of mouse fibroblasts. They exhibit partial cross-resistance to wheat germ agglutinin, a lectin with a saccharide specificity similar to phallolysin. These results are consistent with phallolysin acting by binding to cell surface glycoprotein receptors rather than by interacting directly with lipid components of the membrane.

AB - W. T. Shier, D. J. DuBourdieu and H. Kawaguchi. Selection for resistance to phallolysin, a cytolytic toxin from the death-cap mushroom (Amanita phalloides), Toxicon 21, 447 - 450, 1983. - Phallolysin-resistant variants are readily selected from unmutagenized populations of mouse fibroblasts. They exhibit partial cross-resistance to wheat germ agglutinin, a lectin with a saccharide specificity similar to phallolysin. These results are consistent with phallolysin acting by binding to cell surface glycoprotein receptors rather than by interacting directly with lipid components of the membrane.

UR - https://www.scopus.com/pages/publications/0020959653

UR - https://www.scopus.com/pages/publications/0020959653#tab=citedBy

U2 - 10.1016/0041-0101(83)90103-4

DO - 10.1016/0041-0101(83)90103-4

M3 - Article

C2 - 6684808

AN - SCOPUS:0020959653

SN - 0041-0101

VL - 21

SP - 445

EP - 448

JO - Toxicon

JF - Toxicon

IS - 3

ER -

Selection for resistance to phallolysin, a cytolytic toxin from the death-cap mushroom (Amanita phalloides)

Abstract

Bibliographical note

Publisher link

Find It

Other files and links

Fingerprint

Cite this